Research Article

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2/16/2017
Adult; Aged; Aged, 80 and over; Arabs; Colorectal neoplasms; Exons; Female; Humans; male; Middle Aged; Mutation; Mutation Rate; Prognosis; Proto-Oncogene Proteins p21(ras); Retrospective Studies; Saudi Arabia; Survival analysis; Young Adult

Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian patients with CRC. The genetic status of K-ras was determined in ... more

J. Zekri; A. Al-Shehri; M. Mahrous; S. Al-Rehaily; T. Darwish; S. Bassi; E. Taani; A. Zahrani; S. Elsamany; J. Al-Maghrabi; B.B. Sadiq
2/23/2017
cluster analysis; Fruit; Genetic variation; Genotype; Hybridization, Genetic; Microsatellite instability; Microsatellite Repeats; Musa; Mutation; Plant breeding; Reproducibility of Results; Species Specificity

Banana (Musa spp) is a fruit species frequently cultivated and consumed worldwide. Molecular markers are important for estimating genetic diversity in germplasm and between genotypes in breeding programs. The objective of this study was to analyze the genetic diversity of 21 banana genotypes (FHIA 23, PA42-44, Maçã, Pacovan Ken, Bucaneiro, YB42-47, Grand Naine, Tropical, FHIA 18, PA94-01, YB42 ... more

A.V.C. Silva; A.L.S. Nascimento; M.F. Vitória; A.R.C. Rabbani; A.N.R. Soares; A.S. Lédo
2/23/2017
Capsicum; Cytoplasm; Fertility; Flowers; Genes, Plant; Genetic markers; Genotype; Hybridization, Genetic; Meristem; Mutation; Phenotype; Plant breeding; Plant Infertility; Reproducibility of Results; seeds

Cytoplasmic male sterility (CMS) in pepper is a better way to produce hybrid seeds compared to manual production. We used the two sequence characterized amplified region (SCAR) markers (CRF-SCAR and CMS-SCAR) in CMS pepper, to identify the genotype. We assembled two CMS yellow bud mutants (YBM; YBM12-A and YBM12-B). This mutation in leaf color is controlled by a single dominant nuclear gene. ... more

G.S. Sun; Z.L. Dai; P.W. Bosland; Q. Wang; C.Q. Sun; Z.C. Zhang; Z.H. Ma
3/30/2017
Avena; Chromosomes, Plant; Flowers; Homeodomain Proteins; Mutation; Nuclear Proteins; Phenotype; Plant Proteins

Multiflorous spikelets are found in several grass species of agricultural and economic interest. In oat, this morphological characteristic is associated with the production of naked grains. Although many genetic studies have been performed over the past century, the inheritance of the multiflorous spikelet trait is not fully understood in oat. The objectives of this study were to evaluate ... more

C.M. Zimmer; I.P. Ubert; K. Pellizzaro; L.C. Federizzi; I.C. Nava
4/5/2017
Alleles; Brazil; Gene frequency; Genetic association studies; Haplotypes; Humans; Huntingtin Protein; Huntington Disease; Mutation; Trinucleotide repeat expansion

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by a dynamic mutation due to the expansion of CAG repeats in the HTT gene (4p16.3). The considered normal alleles have less than 27 CAG repeats. Intermediate alleles (IAs) show 27 to 35 CAG repeats and expanded alleles have more than 35 repeats. The IAs apparently have shown a normal phenotype. ... more

T.A. Apolinário; C.L.A. Paiva; L.A. Agostinho
4/20/2017
Ascomycota; Brazil; Ecosystem; Evolution, Molecular; Fungal Proteins; Mutation; Peptide Elongation Factor 1; Phylogeography; Polymorphism, Genetic; Selection, Genetic

Lasiodiplodia theobromae is a plant pathogen with a worldwide distribution, with low host specificity, causing stem cankers, dieback diseases, and fruit rot in several species of plants. In coconut, this pathogen is reported as the etiological agent of "coconut leaf blight" (CLB) disease, causing several losses in fruit production. The CLB is an important disease for this crop in Brazil. In ... more

P.H.D. Santos; B.M. Carvalho; K.P. Aguiar; F.A.S. Aredes; T.P.S. Poltronieri; J.M.S. Vivas; M. Dias; G.A. Bezerra; D.B. Pinho; M.G. Pereira; S.F. Silveira
4/28/2017
Biomarkers, Tumor; Carcinoma, Signet Ring Cell; CDX2 Transcription Factor; Codon; Female; Genes, ras; Humans; male; Middle Aged; Mucins; Mutation; Mutation Rate; Neoplasm Metastasis; Phenotype; Stomach neoplasms

We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. Immunohistochemistry was performed on 163 SRC carcinoma patient specimens to detect gastric (MUC1, MUC5AC, and MUC6) and intestinal (MUC2 and CDX2) phenotypic markers, and tumors were ... more

Z.F. Xiong; J. Shi; Z.H. Fu; H.P. Wan; L.X. Tu
8/31/2017
Bacterial Proteins; Flagella; Membrane Proteins; Movement; Mutation; Open Reading Frames; Protein Binding; Protein domains; Virulence; Xanthomonas

Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp citri (Xac), severely affects most economically important citrus varieties worldwide. A previous study showed that disruption of the ORF XAC1201 from the Xac 306 strain by transposon Tn5 decreased bacterium virulence in the Rangpur lime host (Citrus limonia L. Osbeck). However, little is known regarding the possible ... more

F.C.F. Vieira; A.M. Gonçalves; E.F.R. Mendoza; R.M. Ferreira; M.L.M. Costa; T.S. Balbuena; H.G. Sebinelli; P. Ciancaglini; J.M.Pizauro Junior; J.A. Ferro
12/13/2021
Coronavirus; COVID-19; D614G; Mutation; Population genetics; SARS-CoV-2

The COVID-19 pandemic is caused by the worldwide spread of the RNA virus SARS-CoV-2. Because of its mutational rate, wide geographical distribution, and host response variance this coronavirus is currently evolving into an array of strains with increasing genetic diversity. Most variants apparently have neutral effects for disease spread and symptom severity. ... more

F. Antoneli; T.N. Furuyama; I.M.V.G. Carvalho; M.R.S. Briones; L.M.R. Janini
09/21/2015
Breast cancer; GIT2; Metastasis; MTERF; Multiplex RT-PCR

Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive markers for metastatic risk. This multiplex ... more

S. Sirirattanakul; P. Wannakrairot; T. Tencomnao; R. Santiyanont

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