Research Article

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12/03/2015
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Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and ... more

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Meta-analysis; Polymorphism; TNF-α; Urogenital cancer

We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the ... more

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Human leukocyte antigen-DRB1; Meta-analysis; Tuberculosis

Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association ... more

B.F. Chen; R. Wang; Y.J. Chen; Y. Zhu; L. Ding; Y.F. Wen
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Hepatocellular carcinoma; Meta-analysis; T241M polymorphism; XRCC3

Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese ... more

R.B. Ji; Y.S. Qian; A.R. Hu; Y.R. Hu
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Colorectal cancer; Meta-analysis; Non-metastatic protein 23; Pathological characteristics; Prognosis

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J.W. Fu; X.Q. Chu
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Coronavirus; Meta-analysis; Real-time PCR

Novel coronavirus (nCoV) belongs to the Coronaviridae family, which includes the virus that causes SARS, or severe acute respiratory syndrome. However, infection source, transmission route, and host of nCoV have not yet been thoroughly characterized. In some cases, nCoV presented a limited person-to-person transmission. Therefore, early diagnosis of nCoV may be of importance for reducing ... more

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Hepatocellular carcinoma; HLA-DP; Meta-analysis; SNP

The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out ... more

X. Zhang; C. Zheng; Z.H. Zhou; M. Li; Y.T. Gao; S.G. Jin; X.H. Sun; Y.Q. Gao
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Diabetic peripheral neuropathy; Homocysteine; Meta-analysis; Pathogenesis; Sulfhydryl amino acid; Vascular endothelial cell

The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DPN. We screened the Embase, Ovid, PubMed, Web of Science, Wangfang, and China National ... more

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Hypoxic-ischemic encephalopathy; Meta-analysis; S-100β protein

The clinical significance of serum S-100β levels in neonates with hypoxic-ischemic encephalopathy (HIE), as a reference index to assess HIE severity, was evaluated in this study. On the basis of our strict inclusion and exclusion criteria, relevant high-quality case-control studies reporting the association between HIE and S-100β protein were selected from electronic database searches. The ... more

L.H. Shi; Y. Zhou; M.F. Guo; J.S. Liu; C.X. Li; G.F. Wang; W. Liu; L. Tian
11/26/2015
CYP4F2; Gene polymorphism; Hypertension; Meta-analysis

Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the CYP4F2 gene rs2108622 polymorphism and ... more

X.H. Luo; G.R. Li; H.Y. Li

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