Research Article

Related GMR Articles

08/28/2015
Androgen receptor; Breast cancer; Short tandem repeat

The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and 183 healthy ... more

J. Dang; L. Peng; H.J. Zhong; Z.H. Huo
08/10/2015
Breast cancer; S-phase kinase-associated protein 2; siRNA interference; SKP2

We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2 in breast cancer patient ... more

Y.J. Sun; X.K. Wang; B.J. Li
12/29/2015
Breast cancer; Canine; Chromosome alterations; Cytogenetics; Neoplasm

Currently, mammary neoplasms in female canines are a serious problem in veterinary clinics. In addition, the canine species is an excellent disease model for human oncology because of the biological and genetic similarities between the species. Cytogenetics has allowed further study of the characterization of neoplasms in canines. We hypothesized that the use of a direct preparation ... more

C.S.D. Morais; P.R.A.M. Affonso; J.A. Bitencourt; A.A. Wenceslau
12/22/2015
Breast cancer; Clinicopathology; MicroRNA-125

Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NATs) was measured by real-time ... more

H. He; F. Xu; W. Huang; S.Y. Luo; Y.T. Lin; G.H. Zhang; Q. Du; R.H. Duan
12/21/2015
Breast cancer; G10398A mutation; Haplogroup

Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case- ... more

Y. Yu; F. Lv; H. Lin; G. Qian; Y.S. Jiang; L.X. Pang; Y.P. Wang; X.F. Wang; Y.M. Kang; C.B. Li; Q. Liu; J.Z. Xu; W. You
11/23/2015
BRAF; Breast cancer; KRAS; Mutation; PIK3CA

Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation. Abnormalities in relevant genes play essential roles in the occurrence and development of many human cancers. Studies of breast cancer have mainly focused on the women in western countries, but few studies have examined the frequency of mutations in PIK3CA, BRAF ... more

Y.L. Wang; X. Dai; Y.D. Li; R.X. Cheng; B. Deng; X.X. Geng; H.J. Zhang
10/26/2015
Breast cancer; Chemotherapy response; GSTM1 polymorphism; Mexican population

The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in the mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 ... more

O. Soto-Quintana; G.M. Zúñiga-González; R. Ramírez-Patiño; A. Ramos-Silva; L.E. Figuera; D.I. Carrillo-Moreno; I.A. Gutiérrez-Hurtado; A.M. Puebla-Pérez; B. Sánchez-Llamas; M.P. Gallegos-Arreola
10/27/2015
BRCA1; BRCA2; Breast cancer; Kazakh; mutations

Mutations in the BRCA1/2 genes are associated with an increased risk of breast cancer, but no large-scale research have examined the BRCA1/2 mutations in Chinese Kazakh women. We evaluated the frequency and distributions of BRCA1 and BRCA2 gene mutations in Kazakh sporadic breast cancer patients and healthy women in China. The association between the clinical-pathologic features ... more

S.Y. Yang; D. Aisimutula; H.F. Li; Y. Hu; X. Du; J. Li; M.X. Luan
10/16/2015
Breast cancer; Chinese women; Exome sequencing; SPOP gene

SPOP protein has been found to have ubiquitin ligase activity. Mutations in SPOP gene have been recently reported in some cancers such as prostate, gastric, colorectal cancer. We investigated SPOP DNA mutation in tumor tissues collected from 70 Chinese female breast cancer patients in Southwestern China by DNA sequencing. The results did not show mutation in our tissue samples, indicating ... more

M.A. Khan; L. Zhu; M. Tania; X.L. Xiao; J.J. Fu
02/11/2016
Breast cancer; ILIA; Insertion/deletion; miRNA; Polymorphism

The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically ... more

X. Huang; Y. Yang; Z.W. Cui; J. Wang; L.B. Gao; X. Huang; Y. Yang; Z.W. Cui; J. Wang; L.B. Gao

Pages