Research Article

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12/01/2015
Hypertension; klotho gene; Single nucleotide polymorphism

The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The ... more

L.L. Gao; X. Ding; D.M. Xie; M. Yang; B.R. Dong
09/09/2015
Chronic obstructive pulmonary disease; Gene polymorphism; Meta-analysis; Vitamin D-binding protein

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene ... more

Y.L. Wang; H. Kong; W.P. Xie; H. Wang
09/21/2015
COL1A1; Gene polymorphism; Meta-analysis; Osteoporosis

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
08/19/2015
Cervical carcinoma; Gene polymorphism; Meta-analysis; XRCC1

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and ... more

D.Y. Liu; H.C. Liang; X.M. Xiao
08/07/2015
AT1R; Gene polymorphism; Heart failure; Meta-analysis

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the ... more

J.A. Zhang; J.R. Li; Y.J. Qiao
09/28/2015
Case-control study; Dental caries; Gene polymorphism; Vitamin D receptor

Environmental influences on the development and progression of dental caries are well known; however, there is little evidence of a genetic component imparting susceptibility to dental caries. The aim of this study was to investigate the relationship between a single nucleotide polymorphism in the vitamin D receptor TaqI locus and dental caries susceptibility in a Chinese ... more

X.P. Hu; Z.Q. Li; J.Y. Zhou; Z.H. Yu; J.M. Zhang; M.L. Guo
09/09/2015
Arg188His; Gene polymorphism; Ovarian cancer; X-ray repair cross-complementing group 2 (XRCC2)

Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-analysis. Quality ... more

M. Zhai; Y. Wang; M.F. Jiang
09/08/2015
DQA gene; Gene polymorphism; Haplotype reconstruction; Piglet diarrhea; Swine leukocyte antigen

In this study, 290 Chinese native Yantai black pig piglets were investigated to identify gene polymorphisms, for haplotype reconstruction, and to determine the association between piglet diarrhea and swine leukocyte antigen (SLA) class II DQA exons 2, 3, and 4 by polymerase chain reaction-single stranded conformational polymorphism and cloning sequencing. The results showed that ... more

X.Y. Huang; Q.L. Yang; J.H. Yuan; S.B. Gun
08/10/2015
APOA5/A4/C3/A1 gene cluster; Apolipoprotein B; Dyslipidemia; Gene polymorphism

We determined the alleles of ten single nucleotide poly­morphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 pa­tients and 250 normal controls. All ... more

H.J. Ou; G. Huang; W. Liu; X.L. Ma; Y. Wei; T. Zhou; Z.M. Pan
07/27/2015
Chinese population; Familial aggregation; Gene polymorphism; Liver cancer; Risk factors; Transforming growth factor-β1

The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms in TGF ... more

P.Q. Wan; J.Z. Wu; L.Y. Huang; J.L. Wu; Y.H. Wei; Q.Y. Ning

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