Research Article

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12/29/2015
Early-onset preeclampsia; Interleukin-10; Polymorphism

In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in ... more

Q.Y. Liu; F.Y. Gao; X.R. Liu; J. Li; M. Ji; J. Dong; X.T. Wang
12/29/2015
Association study; Polymorphism; RAGE; susceptibility; Ulcerative colitis

Ulcerative colitis (UC) is an immune-related disease with genetic predisposition. The aim of this study was to investigate the association of three polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with UC risk in a Chinese population. This case-control study involved 72 UC patients and 479 age- and gender-matched healthy controls. Genotyping was ... more

Z.T. Wang; L.Y. Wang; L. Wang; S. Cheng; R. Fan; J. Zhou; J. Zhong
12/29/2015
Benign prostatic hyperplasia; Lymphotoxin beta receptor; Polymorphism; Prostate

The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 ( ... more

S.H. Lee; S.K. Kim; K.H. Yoo; J.H. Chung; S.G. Chang
12/28/2015
Genetic relationship; PCR; Polymorphism; RAPD

The artichoke (Cynara scolymus L.) is an important food and medicinal crop that is cultivated in Mediterranean countries. Morphological characteristics, such as head shape and diameter, leaf shape, and bract shape, are mainly affected by environmental conditions. A molecular marker approach was used to analyze the degree of polymorphism between artichoke hybrid lines. The degree ... more

M.A. Sharaf-Eldin; A. Al-Tamimi; P. Alam; S.F. Elkholy; J.R. Jordan
12/22/2015
Inflammation; Interleukin-10; Periodontal disease; Polymorphism

Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated ... more

R. Hannum; F.R. Godoy; A.S. da Cruz; T.C. Vieira; L.B. Minasi; deM. e Silva; C.C. da Silva; A.D. da Cruz
12/21/2015
Abdominal aortic aneurysm; Interleukin-10; Polymorphism

In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and gender-matched healthy ... more

F. Wang; Q.Q. Quan; C.L. Zhang; Y.B. Li; T.B. Jiang
12/14/2015
Breast cancer; KRAS; let-7; Polymorphism

Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, ... more

X. Huang; Y. Yang; Y. Guo; Z.L. Cao; Z.W. Cui; T.C. Hu; L.B. Gao
12/11/2015
Breast cancer; Chemotherapy; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment ... more

P. Yuan; L. Yuan; B.L. Xu; C.Z. Wang; H.Z. Yang; Y. Li
12/09/2015
Breast cancer; MTHFR; Polymorphism; Risk

We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length ... more

X.F. Zhang; T. Liu; Y. Li; S. Li
12/09/2015
NLRP3; Polymorphism; Primary gout

We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain ... more

L.F. Wang; Y.J. Ding; Q. Zhao; X.L. Zhang

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