Research Article

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12/16/2015
Ankylosing spondylitis; Matrix metalloproteinases-3; Meta-analysis; Serum level

Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching the following databases: PubMed, Embase, ... more

J.W. Gao; K.F. Zhang; J.S. Lu; T. Su
12/08/2015
Ahr; Breast cancer; Gene; Meta-analysis; Polymorphism

Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer. The protocol was approved by ... more

Y. Li; H.Z. Qin; Q. Song; X.D. Wu; J.H. Zhu
12/11/2015
Head and neck cancer; Meta-analysis; MicroRNAs; Screening

Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search for relevant studies up to August ... more

M. Zhang; L.J. Zhao; W.Q. Liang; Z.P. Mao
12/03/2015
Autoimmune disease; Human leukocyte antigen-G; Indel polymorphism; Meta-analysis; susceptibility

Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and ... more

S.K. Kim; K.H. Jeong; I.J. Kang; J.H. Chung; M.K. Shin; M.H. Lee
12/07/2015
Meta-analysis; Polymorphism; TNF-α; Urogenital cancer

We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the ... more

J. Cai; M.Y. Yang; N. Hou; X. Li
12/03/2015
Human leukocyte antigen-DRB1; Meta-analysis; Tuberculosis

Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association ... more

B.F. Chen; R. Wang; Y.J. Chen; Y. Zhu; L. Ding; Y.F. Wen
12/07/2015
Hepatocellular carcinoma; Meta-analysis; T241M polymorphism; XRCC3

Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese ... more

R.B. Ji; Y.S. Qian; A.R. Hu; Y.R. Hu
12/02/2015
Colorectal cancer; Meta-analysis; Non-metastatic protein 23; Pathological characteristics; Prognosis

The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians. English and Chinese language-based electronic databases (e.g., PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wanfang databases, China National Knowledge Infrastructure, VIP ... more

J.W. Fu; X.Q. Chu
12/02/2015
Coronavirus; Meta-analysis; Real-time PCR

Novel coronavirus (nCoV) belongs to the Coronaviridae family, which includes the virus that causes SARS, or severe acute respiratory syndrome. However, infection source, transmission route, and host of nCoV have not yet been thoroughly characterized. In some cases, nCoV presented a limited person-to-person transmission. Therefore, early diagnosis of nCoV may be of importance for reducing ... more

C. Lin; R. Ye; Y.L. Xia
12/02/2015
Hepatocellular carcinoma; HLA-DP; Meta-analysis; SNP

The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out ... more

X. Zhang; C. Zheng; Z.H. Zhou; M. Li; Y.T. Gao; S.G. Jin; X.H. Sun; Y.Q. Gao

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