Research Article

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07/06/2015
Cirrhosis; Meta-analysis; Proton pump inhibitor; Spontaneous bacterial peritonitis

We used a meta-analysis approach to investigate the association between proton pump inhibitor (PPI) use and risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. We searched Ovid Medline, Embase, and the Cochrane Library to identify eligible studies. We included studies that compared cirrhotic patients who did or did not use PPIs. The primary outcome was SBP, and the ... more

H.B. Xu; H.D. Wang; C.H. Li; S. Ye; M.S. Dong; Q.J. Xia; A.Q. Zhang; K. Pan; X.L. Ge; J.H. Dong
07/03/2015
HNF1B rs4430796 (A>G) polymorphism; Meta-analysis; Prostate cancer

Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through May 18, 2014, were ... more

Y. Zhao; J. Liang; J.G. Qi; N. Yang; G. Wu; Y.L. Lin; J.Y. Cao; Q. Wang; Q.C. Wang
07/03/2015
Diagnosis; Meta-analysis; MicroRNAs; Thyroid cancer

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive ... more

G.J. Zhou; M. Xiao; L.N. Zhao; J.G. Tang; L. Zhang
12/29/2015
Cardiopulmonary bypass; Interleukin-6; Interleukin-8; Meta-analysis; Sevoflurane

This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB). The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used. In ... more

Q.B. Yu; H.M. Li; L.L. Li; S.Y. Wang; Y.B. Wu
12/29/2015
Cancer; MALAT1; Meta-analysis; Pathological features; Prognosis; Protein expression

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a potential cancer biomarker, yet the mechanism by which it influences the development of cancer remains unknown. In this study, we aimed to correlate MALAT1 expression with pathological features and prognosis in cancer patients. Several databases were searched using combinations of ... more

X.S. Shi; J. Li; R.H. Yang; G.R. Zhao; H.P. Zhou; W.X. Zeng; M. Zhou
12/22/2015
Biomarker; Colorectal cancer; Diagnostic marker; Meta-analysis; MicroRNA-29a

Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based miR-29a for CRC. We performed a ... more

M.L. Zhi; Z.J. Liu; X.Y. Yi; L.J. Zhang; Y.X. Bao
12/22/2015
CXCR4; Meta-analysis; Non-small cell lung cancer; Protein expression

The specific correlation between CXCR4 expression and survival in non-small cell lung cancer (NSCLC) has been investigated independently; however, these have yielded inconsistent results. Therefore, we examined the exact relationship between CXCR4 expression and NSCLC in this meta-analysis. The bibliographic databases in English and Chinese were carefully searched and data regarding the ... more

H. Wang; F. Xie; Z. Hu; L. Chen
12/22/2015
AGER; Breast cancer; Lung cancer; Meta-analysis; Polymorphisms

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National ... more

N.C. Yin; X.P. Lang; X.D. Wang; W. Liu
12/17/2015
CYP1B1; Meta-analysis; Primary open-angle glaucoma; SNP

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, including EMBase, Web of ... more

Z. Wang; M. Li; L. Li; H. Sun; X.Y. Lin
12/14/2015
Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

W. Pan; H. Liao

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