Research Article

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10/30/2015
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The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal controls. The coding regions ... more

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Growth and meat quality traits play important roles in the evaluation of cattle productivity and are influenced by genetic and environmental factors. CRTC2 is a recently discovered gene related to obesity that may influence fat deposition. The aim of the current study was to detect polymorphisms of bovine CRTC2 and explore their relationships to growth and meat quality ... more

H.C. Xu; L.S. Gui; N. Song; Y.Y. Zhang; H. .C.Wang; L.S. Zan
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Hu sheep; mRNA expression; NR5A2; Reproductive performance; Single nucleotide polymorphism

NR5A2 has been implicated in processes as diverse as steroidogenesis, cellular proliferation, ovarian follicular development, ovulation, and fertility in mammals. However, data about the relationship between NR5A2 and prolificacy in mammals are lacking. In the present study, we identified and characterized NR5A2 of Hu sheep, and investigated the correlation ... more

Y.X. Li; J. Zhang; Y. Qian; C.H. Meng; H.L. Wang; X.J. Tao; S. Zhong; S.X. Cao; Q.F. Li
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Cyprinus carpio var. Jian; Elovl5; Growth trait; Single nucleotide polymorphism; Δ6-desaturase

Highly unsaturated fatty acids (HUFAs) are crucial for the nutritional health, physiology, and reproduction of vertebrates. The Δ6-desaturase and Elovl5 elongase genes produce essential enzymes in the biosynthetic pathway of HUFAs. Single nucleotide polymorphism (SNP) analysis of genes functionally related to the growth traits of the common carp (Cyprinus carpio var. Jian) can ... more

H. .Ren; J. Yu; P. Xu; Y. Tang
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The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 controls. ... more

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Cervical cancer; IL-17A; IL-17F; Interleukin-17A; Interleukin-17F; Single nucleotide polymorphism

We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs2275913, rs3748067, and rs3819025) and IL-17F (rs763780, ... more

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ABCG2; Gout; PDK2; Metabolic phenotypes; Single nucleotide polymorphism

Previous studies have shown that the PDK2 and ABCG2 genes play important roles in many aspects of gout development in European populations. However, a detailed genotype-phenotype analysis was not performed. The aim of the present study was to investigate the potential association between variants in these two genes and metabolism-related quantitative phenotypes relevant ... more

Y.C. Ren; T.B. Jin; X.D. Sun; T.T. Geng; M.X. Zhang; L. Wang; T. Feng; L.L. Kang; C. Chen; Y.C. Ren; T.B. Jin; X.D. Sun; T.T. Geng; M.X. Zhang; L. Wang; T. Feng; L.L. Kang; C. Chen
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Admixed population; African ancestry; Amerindian ancestry; Ancestry informative markers; European ancestry; Single nucleotide polymorphism

Some studies of polymorphisms in prostate cancer (PCa) analyze individuals in a uniform manner, regardless of genetic ancestry. However, PCa aggressiveness differs between subjects of African descent and those of European extraction. Thus, genetic ancestry analysis may be used to detect population stratification in case-control association studies. We genotyped 11 ... more

J.S. Oliveira; R.S. Ferreira; L.M. Santos; L.J. Marin; R.X. Corrêa; M.R. Luizon; A.L. Simões; S.R. Gadelha; S.M.B. Sousa
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Ankylosing spondylitis; IL-4 rs2227282; IL-4 rs2243250; Interleukin-4; Serum levels; Single nucleotide polymorphism

We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the control group. IL-4 ... more

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Chinese Han population; Dopamine D2 receptor; Heroin dependence; Single nucleotide polymorphism

Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and ... more

N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li; N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li

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