Research Article

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Cardiovascular disease; Glutathione S-transferase; Malaysia; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the effect of GST polymorphisms on the ... more

A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail
01/31/2022
Brazilian population; Genetic epidemiology; Genetic susceptibility; Polymorphisms; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a chronic, complex, multifactorial and polygenic disease, constituting one of the greatest public health challenges worldwide. The genetic background has been shown to strongly influence the disease’s susceptibility. We performed genetic screening of risk-variants for T2DM and complications in the Brazilian population. This ... more

J.S. Campos; K.F. Santos; C.C.P. Costa; J.B.S. Barros; V.S.S. Gonçalves; L.P. Assunção; A.A.S. Reis; R.S. Santos
03/14/2023
Gliclazide; Metformin; SLC2A2 gene; Type 2 diabetes mellitus; Vietnam

In recent years, the number of people with type 2 diabetes mellitus has increased rapidly and it has become an important public health problem in Vietnam. To provide valuable information on the efficacy and safety of diabetes medications (metformin and gliclazide), we evaluated how they affected the expression level and mutations of the SLC2A2 gene in the liver of ... more

D.M. Nguyen; M.T. Nguyen; T.T.Bich Vo; M.N. Nghiem; S.T. Dao
09/25/2015
Diabetes; Insulin resistance; Visceral adipose tissue-derived serpin

We investigated serum visceral adipose tissue-derived serpin (vaspin) levels in patients with normal glucose regulation and recently diagnosed type 2 diabetes (T2DM) and explored the association between vaspin and body mass index, age, gender, glucose, lipid metabolism, and insulin sensitivity. Fasting serum vaspin levels in 66 patients with T2DM and 48 normal subjects were detected using ... more

L. Yang; S.J. Chen; G.Y. Yuan; D. Wang; J.J. Chen
07/14/2015
Gestational diabetes mellitus; Insulin resistance; Lipoprotein lipase gene polymorphism

The aim of this study was to investigate the relationship between a lipoprotein lipase (LPL) gene polymorphism in placental tissue and insulin resistance (IR) in patients with gestational diabetes mellitus. Using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) analysis, the LPL HindIII RFLP was examined in the placental tissue of 110 ... more

D.D. Li; D.Y. Su; L. Xue; W. Gao; W.Y. Pang
02/11/2016
Fasting blood glucose; Insulin resistance; Resistin; Traumatic brain injury

Resistin (RSTN) expression in subcutaneous adipose tissue, and its effect on glucose metabolism in rats with traumatic brain injury, was investigated using real-time PCR, western blots, and enzyme linked immunoassays. Our results show that the expression of RSTN mRNA (3.192 ± 0.046, 4.016 ± 0.010, 6.004 ± 0.020, 8.213 ± 0.013, 11.199 ± 0.174, 15.094 ± 0.030), protein levels (1.79 ± 0.05 ... more

R. Zhang; Z.Y. Wang; L.L. Zhu; F. Wu; D.Q. Chen; L.F. Sun; Z.Q. Lu; R. Zhang; Z.Y. Wang; L.L. Zhu; F. Wu; D.Q. Chen; L.F. Sun; Z.Q. Lu
4/28/2017
Adolescent; Blood glucose; Case-control studies; Child; Female; Ghrelin; Humans; Insulin resistance; Lipoproteins; male; Obesity; Triglycerides

Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate the role of obestatin in insulin resistance. A total of 54 children ... more

M.Y. Zhang; F. Li; J.P. Wang
11/29/2017
Endothelial Dysfunction; Exercise Intervention; Impaired Glucose Tolerance; Insulin resistance; Prediabetes Mellitus; Vascular Endothelium
Prediabetes is considered to be an at a risk state, with
an annualized 5-10% conversion rate of diabetes and the similiar
proportion converting back to normoglycaemia. The global
incidence of prediabetes is increasing and will reach to 471 million
patients in 2030. The elevation of blood sugar is a continuum and
hence prediabetes cannot ... more
S. Wang; Z. Zhang; Y. Liu; Z. Wang

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