Research Article

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12/14/2015
Gastric bypass surgery; Gluconeogenesis; Phosphoenolpyruvate carboxykinase; Type 2 diabetes mellitus

The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (control) groups (N = 12 per group ... more

J. Wu; S.S. Hou; W. Wang; M. Yin; N. Cheng; L.L. Ge; J.J. Yin; J. Xu
10/21/2015
Chinese Han population; eNOS; Genetic polymorphisms; MnSOD; Type 2 diabetes mellitus

Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were ... more

J.Y. Li; F. Tao; X.X. Wu; Y.Z. Tan; L. He; H. Lu
12/31/2019
Candidate genes; meat quality; Nutrigenomics; Skeletal muscle; Transcriptomic

We examined the effect of lipid content in the diet on the transcriptome of the Longissimus dorsi muscle in pigs. Our objective was to examine changes at the molecular level affecting economically relevant meat quality characteristics such as intramuscular fat deposition and fatty acid profile. The treatments consisted of isoproteic and isoenergetic diets ... more

M.C. Montenegro; P. Peraza; N. Balemian; C. Carballo; N. Barlocco; P.G. Barrios; B. Mernies; A. Saadoun; G. Castro; S.F. Guimarães; S. Llambí
10/30/2020
Candidate genes; FA; IMF; Muscles tissues; Tan sheep

Ningxia Tan sheep meat is tender, has no strong smell, a delicious taste, and even fat distribution. Intramuscular fat (IMF) content and the composition of fatty acid (FA) both are important factors associated with meat quality, and are also important for meat tenderness and flavor assessment. We examined the correlation of candidate genes expression with these ... more

X. Xu; W. Chen; S. Yu; S. Fan; W. Ma
08/14/2015
Association study; Schizophrenia; SNP; VRK2 gene

Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 ... more

B. Zhang; C.Y. Gao; H.B. Zhang; B. Yang; J.F. Yin; S.G. Wei; Y.S. Zhu; X.N. Jia; S.B. Li
12/29/2015
Association study; Polymorphism; RAGE; susceptibility; Ulcerative colitis

Ulcerative colitis (UC) is an immune-related disease with genetic predisposition. The aim of this study was to investigate the association of three polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with UC risk in a Chinese population. This case-control study involved 72 UC patients and 479 age- and gender-matched healthy controls. Genotyping was ... more

Z.T. Wang; L.Y. Wang; L. Wang; S. Cheng; R. Fan; J. Zhou; J. Zhong
09/16/2016
Association study; CD4; Holstein; Milk fat; Production traits; Single nucleotide polymorphism

Cluster of differentiation 4 gene (CD4) is well known for its role in immunity, but its effects on production traits remain to be elucidated. The present study was designed to explore single nucleotide polymorphisms (SNPs) in the exons, flanking introns, and promoter of CD4, as well as to analyze their effects on milk production traits (percentage of protein, fat, and ... more

T. Usman; Y. Yu; L. Zhai; C. Liu; X. Wang; Y. Wang; T. Usman; Y. Yu; L. Zhai; C. Liu; X. Wang; Y. Wang
03/31/2021
Association study; Calpain; Haplotype; Hypertensive disorders of pregnancy; Variant

Various theories have been developed regarding the pathology and etiology of hypertensive disorders of pregnancy (HDP). The impaired placenta secretes antiangiogenic factors into maternal blood, resulting in the development of pregnancy-induced hypertension (PIH). Both µ-calpain and m-calpain are proteins known to be involved in placentation, with the catalytic ... more

T. Nakayama; T. Nakayama; K. Shinya; E. Shikata; K. Kawana; T. Yamamoto
03/20/2015
Stage of disease; Type 2 diabetes mellitus

There is currently no reported staging system for type 2 diabetes mellitus. Here, I attempted to stage type 2 diabetes mellitus in order to help clinicians, patients, and other interested individuals to effectively evaluate patient conditions.

S.L. Wu
08/21/2015
Chinese Hui population; Polymorphism; TCF7L2; Type 2 diabetes mellitus

Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated ... more

Y. Yang; J.R. Xu; Y.J. Wang; X.M. Liu

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