Research Article

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11/29/2017

Protein Z gene variants and risk of Idiopathic Recurrent Pregnancy Loss in Saudi Arabian women

Idiopathic Recurrent Pregnancy Loss SNP genotyping; Polymorphisms; Protein Z gene
Background: Protein Z (PZ) is a vitamin K-dependent
plasma glycoprotein, it plays a key role in the physiologic inhibition
of coagulation by acting as a cofactor in the inactivation of factor Xa.
The relationship between PZ gene polymorphisms and pregnancy
loss is controversial. To address this, we investigate the association
between PZ ... more
W. Zammiti; S. Saidi; A. Shaman; F.Mohammed A. Duhier
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Evidence of association of glutathione-S-transferase GSTT1 and GSTM1 null genotypes with susceptibility to oral cancer based on meta-analysis

Glutathione-S-transferase; GSTM1; GSTT1; Oral cancer risk; Polymorphisms

The development of oral cancer results from interactions between genetic and environmental factors. Glutathione-S-transferase gene null polymorphisms have a strong impact on the detoxification of carcinogens; therefore they are expected to be related to oncogenic risk, including oral cancer. Various studies have evaluated a possible association of ... more

A.K. Lopes; A.L.M. Tacca; N.A. Nogueira; J.A. Sodario; C.A.S.T. Vilanova-Costa; V.A. Saddi; A.Vde Moraes Filho; A.M.T.C. Silva
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The IL18 rs1946518 and PTPN22 rs2476601 polymorphisms are not associated with adult- and childhood-onset type 1 diabetes mellitus

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Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic β-cells. Interleukins such as interleukin 18 (IL-18) and protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) have been found to be associated with immune related diseases. We investigated a possible association of polymorphisms in IL-18 gene rs1946518 and ... more

L.P. Campos; V. Graciolo; M. Welter; M.S. Lopes; S. Nesi-França; G. Picheth; F.G.M. Rego
01/31/2022

Genetic epidemiology of Type 2 diabetes mellitus and complications in the Brazilian population

Brazilian population; Genetic epidemiology; Genetic susceptibility; Polymorphisms; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a chronic, complex, multifactorial and polygenic disease, constituting one of the greatest public health challenges worldwide. The genetic background has been shown to strongly influence the disease’s susceptibility. We performed genetic screening of risk-variants for T2DM and complications in the Brazilian population. This ... more

J.S. Campos; K.F. Santos; C.C.P. Costa; J.B.S. Barros; V.S.S. Gonçalves; L.P. Assunção; A.A.S. Reis; R.S. Santos
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Lack of association of VEGF-A polymorphisms and susceptibility to amyotrophic lateral sclerosis and multiple sclerosis: A systematic review and meta-analysis

Meta-analysis; Neurodegenerative diseases; Polymorphisms; Systematic review; VEGF-A

Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are degenerative scleroses with unclear etiology. Vascular endothelial growth factor A (VEGF-A) is a growth factor that plays multiple roles in the central nervous system.  Previous studies indicated a potential association between polymorphisms in this gene and the susceptibility of ALS and ... more

J.O. Costa; C.C.P. Costa; N.S. Lima; K.F. Santos; A.A.S. Reis; R.S. Santos
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Genetic polymorphisms of the folate pathway in amyotrophic lateral sclerosis and multiple sclerosis: a systematic review and meta-analysis

Meta-analysis; Neurodegenerative diseases; One-carbon metabolism; Polymorphisms; Systematic review

The folate cycle is a biochemical pathway that plays an important role in the development and maintenance of the nervous system. Biocompounds synthesized in this cycle must be carefully regulated, since the accumulation of some substances can be neurotoxic and increase susceptibility to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and ... more

J.V.A. Neves; N.S. Lima; C.C.P. Costa; K.F. Santos; A.A.S. Reis; R.S. Santos

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