Research Article

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02/01/2023

Genetic polymorphisms of the folate pathway in amyotrophic lateral sclerosis and multiple sclerosis: a systematic review and meta-analysis

Meta-analysis; Neurodegenerative diseases; One-carbon metabolism; Polymorphisms; Systematic review

The folate cycle is a biochemical pathway that plays an important role in the development and maintenance of the nervous system. Biocompounds synthesized in this cycle must be carefully regulated, since the accumulation of some substances can be neurotoxic and increase susceptibility to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and ... more

J.V.A. Neves; N.S. Lima; C.C.P. Costa; K.F. Santos; A.A.S. Reis; R.S. Santos

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