Research Article

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Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
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Osteoporosis is the most common bone disease, affecting millions of people worldwide and leading to significant morbidity and high costs. Monacolin K, an extract of red yeast rice (RYR, Hongqu), plays important roles in the management of dyslipidemia, coronary heart disease, and diabetes. Our study aimed to investigate the protective effect of monacolin K on ovariectomy-induced ... more

Y.F. Wang; W.T. Liu; C.Y. Chen; H.P. Ke; H.L. Jiang; X.L. Chen; S.Y. Shi; W. Wei; X.N. Zhang
07/13/2015
Insulin-like growth factors; Osteoporosis; Polymorphism

We conducted a case-control study to assess the relation­ship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to ... more

W. Zhang; L.C. Zhang; H. Chen; P.F. Tang; L.H. Zhang
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Insulin-like growth factors; Osteoporosis; Polymorphism; Postmenopausal female

The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. ... more

Y.K. Wei; H.L. Ma; Y.Z. Guo; B.H. Yang; W.X. Pang
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Alendronate regulates the activity of osteoclasts and healing of osteoporosis. This study investigated the effect of alendronate on bone healing and changes in the levels of cytokines. Bilateral ovaries of 10 adult female rabbits were removed surgically in aseptic condition to establish the animal model of osteoporosis. Five rabbits in group A were treated with alendronate (1.15 mg·kg·week) ... more

C.T. Liu; X.J. Yuan; G.C. Gao
03/29/2021
Calcium and vitamin D; Cross- sectional; Exercise; Fosamax drug; Lifestyle; Menopause; Osteoporosis; Prevalence; T-score

Osteoporosis is a common pathology and a cause of disability and reduced quality of life invarious developing countries.  An urgent issue in this context is the study of risk factors for osteoporosis, especially those that can be modified. We conducted a cross-sectional study in Vietnam.  The study was conducted in the city of Vinh and involved 2065 respondents who ... more

S.C. Thuc; T.H.L. Thi; M.T.N. Thi; H.D. Vinh
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Bone Density; Fractures; Osteoporosis; Postmenopausal osteopenia; Zoledronic acid

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V.T. Toan; B.V. Anh
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Acute coronary syndromes; Cardiovascular disease; Coronary artery disease; Estrogen receptor 1; Meta-analysis; Myocardial infarction

The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scientific ... more

N. Jiang; G. Yang; C.L. Peng
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Breast cancer; Estrogen receptor 1; Single-nucleotide polymorphism; susceptibility

Estrogen receptor-a (ER) protein plays a key role in breast carcinogenesis, and common genetic variants in the corresponding gene locus have been associated with breast cancer risk in different populations. Here, we analyzed estrogen receptor 1 (ESR1) associations in two hospital-based studies of patients from the south of China. Three single-nucleotide polymorphisms (SNPs; ... more

X. Li; G.Y. Yao; F.X. Li; Y.R. Qiu; X.X. Yang; X. Li; G.Y. Yao; F.X. Li; Y.R. Qiu; X.X. Yang
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Enriched library; Microsatellite markers; Polymorphism; Sika deer

Microsatellite markers are widely and evenly distributed, and are highly polymorphic. Rapid and convenient detection through automated analysis means that microsatellite markers are widely used in the construction of plant and animal genetic maps, in quantitative trait loci localization, marker-assisted selection, identification of genetic relationships, and genetic diversity and phylogenetic ... more

Y.M. Li; C.Y. Bai; W.P. Niu; H. Yu; R.J. Yang; S.Q. Yan; J.Y. Zhang; M.J. Zhang; Z.H. Zhao

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