Research Article

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Chromobacterium violaceum is a versatile, Gram-negative β-protebacterium that grows in a variety of ecosystems in tropical and subtropical areas, such as the water and borders of the Negro River, in the Amazon region of Brazil. Although it is a saprophyte and is generally considered non-pathogenic, sporadic cases of human infection have been described, mainly in young children and in ... more

C.F.Alves de Brito; C.M.B. Carvalho; F.R. Santos; R.T. Gazzinelli; S.C. Oliveira; V. Azevedo; S.M.R. Teixeira
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Dimorphism; Host-pathogen interaction; Paracoccidioides brasiliensis; Pathogenicity; Transcriptome analysis; Virulence

Paracoccidioides brasiliensis, the etiologic agent of paracoccidioidomycosis, is a dimorphic fungus, which is found as mycelia at 22-26ºC and as yeasts at 37ºC. A remarkable feature common to several pathogenic fungi is their ability to differentiate from mycelium to yeast morphologies, or vice-versa. Although P. brasiliensis is a recognized pathogen for humans, ... more

A.Henrique Tavares; S.Souza Silva; V.Vilmar Bernardes; A.Queiróz Maranhão; A.Queiróz Maranhão; C.Maria Kyaw Kyaw; M. Poças-Fonseca; I. Silva-Pereira
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Bacterial Proteins; Flagella; Membrane Proteins; Movement; Mutation; Open Reading Frames; Protein Binding; Protein domains; Virulence; Xanthomonas

Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp citri (Xac), severely affects most economically important citrus varieties worldwide. A previous study showed that disruption of the ORF XAC1201 from the Xac 306 strain by transposon Tn5 decreased bacterium virulence in the Rangpur lime host (Citrus limonia L. Osbeck). However, little is known regarding the possible ... more

F.C.F. Vieira; A.M. Gonçalves; E.F.R. Mendoza; R.M. Ferreira; M.L.M. Costa; T.S. Balbuena; H.G. Sebinelli; P. Ciancaglini; J.M.Pizauro Junior; J.A. Ferro
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Inert surfaces favor the persistence of Staphylococcus aureus, as they are reservoirs and means of contamination in hospital and clinical environments. The pathogenicity of this bacterium is controlled by the accessory gene regulatory (agr) system. We examined virulence and toxin genes in isolated strains of S. aureus on inert surfaces ... more

A.C. Pavón; P.P. Orellana; C.F. Andrade; J.E. Torracchi; M.J. Guillén; D.G. Carchi
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Capsicum annuum; Defense-related gene expression; Enzyme activity; Phytophthora blight; Phytophthora capsici Leonian

Based on culture isolation and morphological observation blight-infected pepper plants in Shaanxi Province, China, we identified the pathogen causing pepper phytophthora blight as Phytophthora capsici. Varieties that differed in resistance (CM334, PBC602, and B27) were inoculated with this pathogen. The root activity of resistant CM334 variety was the highest while that of ... more

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Cold stress; Enzyme activity; Lycopersicum esculentum L.; Real-time PCR; Superoxide dismutase; Tomato

The current study was designed to evaluate lipid peroxidation (via malondialdehyde) levels, the superoxide dismutase (SOD) gene expression profile, and SOD enzyme activity in tomato plants (Lycopersicum esculentum L.) subjected to different time periods of cold stress (control, 2, 4, 6, 8, and 10 days). Results revealed that maximum lipid peroxidation occurred in ... more

S. Aydin; İ. Büyük; S. Aras
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Alpha-particle radiation; Arabidopsis embryos; Enzyme activity; Reactive oxygen species

Alpha (a)-particle radiation has been thoroughly studied in the occupational and residential environments, but biological mechanisms induced by a-particle radiation on plants are not clearly understood. In this study, radiation effects were examined using different total doses (1, 10, 100 Gy, respectively) of 241Am, a-particle on Arabidopsis embryos. No significant difference in ... more

J. Ren; L. Liu; X.L. Jin; S.L. Fu; Z.C. Ding
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Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Colorectal neoplasms; Curcumin; Drug Resistance, Neoplasm; Heat-shock proteins; HSP27 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Molecular chaperones; Proto-Oncogene Proteins c-bcl-2; Survivin

Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combination with curcumin on HCT-8/5 ... more

Y.X. Fan; P. Abulimiti; H.L. Zhang; Y.K. Zhou; L. Zhu