Research Article

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08/21/2015
Clinical outcome; ERCC1; ERCC2; Osteosarcoma; Polymorphism

We aimed to evaluate the influence of four SNPs in ERCC1 and ERCC2 on the response to cisplatin-based treatment and on clinical outcome in patients with osteosarcoma. We identified 186 patients with osteosarcoma diagnosed between April 2009 and April 2011 who were eligible for inclusion in our study. Genotyping of ERCC1 rs11615, rs3212986, and rs2298881; and ... more

Z.H. Cao; H.P. Yin; N. Jiang; B. Yu
08/21/2015
Burn; Plasminogen activator inhibitor-1; Polymorphism; Sepsis

We investigated the association between plasminogen activator inhibitor-1 (PAI-1) polymorphisms and plasma PAI-1 level with sepsis in severely burned patients. A total of 182 patients with burn areas lager than 30% of the body surface area were enrolled in this study. Peripheral blood samples were obtained from 103 patients with sepsis (sepsis group) and 79 patients without sepsis ( ... more

Y.F. Chi; J.K. Chai; Y.M. Yu; H.M. Luo; Q.X. Zhang; R. Feng
08/14/2015
Alopecia areata; Case-control study; CXCL1; CXCL2; Polymorphism

Alopecia areata (AA) is a common disease, which causes hair loss in humans. AA has a genetically complex inheritance. This study investigated the possible correlations between single nucleotide polymorphisms (SNPs) in the promoter regions of the chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2 ... more

S.K. Kim; J.H. Chung; H.J. Park; S.W. Kang; D.J. Lim; S.H. Byun; D.G. Baek; H.Y. Ko; B.L. Lew; H.H. Baik; W.Y. Sim
08/10/2015
Alzheimer’s disease; Estrogen receptor; Meta-analysis; Polymorphism

The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms. A ... more

Y.H. Lee; G.G. Song
08/07/2015
Esophageal cancer; Meta-analysis; p53 codon 72; Polymorphism

Although many epidemiologic studies have investigated the p53 codon 72 polymorphism and its association with esophageal cancer (EC) in China, definite conclusions could not be drawn. To clarify the effects of p53 codon 72 polymorphism on the risk of EC, we performed a meta-analysis on the Chinese population. A total of 13 studies including 3308 patients and 5115 controls were involved in ... more

J.Z. Peng; L. Xue; D.G. Liu; Y.H. Lin
07/31/2015
Meta-analysis; Polymorphism; Pulmonary tuberculosis; Tumor necrosis factor

The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls ... more

Y.H. Lee; G.G. Song
07/28/2015
Gastric cancer; Meta-analysis; MicroRNA; Polymorphism

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

Y.P. Gu; Q.Y. Yuan; H. Zhang; C.J. Wang; F. Zhou
07/28/2015
Hepatitis B virus; MIF-173G/C; Polymorphism

In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, the MIF -173G/C ... more

Z.S. Wang; C.C. Yin; S. Han; F.L. Jiang; W.G. Guo; L.Q. Wu; S.H. Liu
07/28/2015
Interleukin-17; Polymorphism; Pulmonary tuberculosis

We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 were analyzed using ... more

G.C. Shi; L.G. Zhang
07/17/2015
Breeding; Germplasm bank; Pepper; Polymorphism; Simple sequence repeat

In order to support further genetic, diversity, and phy­logeny studies of Capsicum species, the transferability of a Capsicum annuum L. simple sequence repeat (SSR) microsatellite set was ana­lyzed for C. frutescens L. (“malagueta” and “tabasco” peppers) and C. chinense Jacq. (smell peppers, among other types). A total of 185 SSR primers were evaluated ... more

S.I.C. Carvalho; C.F. Ragassi; I.B. Oliveira; Z.P.S. Amaral; F.J.B. Reifschneider; F.G. Faleiro; G.S.C. Buso

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