Research Article

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12/29/2015
Early-onset preeclampsia; Interleukin-10; Polymorphism

In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in ... more

Q.Y. Liu; F.Y. Gao; X.R. Liu; J. Li; M. Ji; J. Dong; X.T. Wang
12/29/2015
Interleukin-10; Meta-analysis; Nasopharyngeal carcinoma; Polymorphism; Promoter genes

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort ... more

Y.F. Yu; Z.G. Han; W.B. Guo; G.J. Zhang; J.K. Yang; F.L. Wu; Q.Y. Ou; Y.H. Li; X.Y. Cai; Z.N. Zhan; J.H. Chen; W.L. Xie; L. Tang; C.D. Liu
12/22/2015
Inflammation; Interleukin-10; Periodontal disease; Polymorphism

Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated ... more

R. Hannum; F.R. Godoy; A.S. da Cruz; T.C. Vieira; L.B. Minasi; deM. e Silva; C.C. da Silva; A.D. da Cruz
12/21/2015
Abdominal aortic aneurysm; Interleukin-10; Polymorphism

In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and gender-matched healthy ... more

F. Wang; Q.Q. Quan; C.L. Zhang; Y.B. Li; T.B. Jiang
05/09/2016
-1082A/G; -819T/; Acute pancreatitis; Interleukin-10; Polymorphism

Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese individuals. In total, 182 patients with confirmed cases of ... more

B.Z. Jiang; L. Tang; H. Xue; D.P. Liu; B.Z. Jiang; L. Tang; H. Xue; D.P. Liu
12/03/2015
Coronary artery disease; Interleukin-10; Polymorphism

The aim of this study was to investigate the association between three common SNPs (-1082A/G, -819T/C, and -592A/C) in the interleukin 10 (IL-10) gene, and the development of coronary artery disease. Between January 2013 and December 2014, 272 patients with coronary artery disease and control subjects (each) were recruited for this study from the Huaihe Hospital of Henan University. ... more

H.M. Xu; Y.R. Liu
02/22/2016
Chronic hepatitis B; Interleukin-10; Liver cirrhosis; Polymorphism

We conducted a case-control study to assess the role of two IL10 gene polymorphisms (rs1800896 and rs1800872) in susceptibility to liver cirrhosis, and their association with chronic hepatitis B in a Chinese population. A case-control study was designed to investigate the association between functional polymorphisms of IL10 (rs1800896 and rs1800872) and the development ... more

L.N. Cao; S.L. Cheng; W. Liu; L.N. Cao; S.L. Cheng; W. Liu
06/03/2016
Interleukin-10; Meta-analysis; Pediatric asthma; Polymorphism

The results of previous epidemiological studies exploring the relationship between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to pediatric asthma are not consistent. Therefore, we have performed a systematic review and meta-analysis to provide a more convincing conclusion. Odds ratios (OR) with their 95% confidence intervals (CIs) were used to evaluate the ... more

Z.Y. Huang; B.J. Cheng; Y. Wan; C. Zhou; Z.Y. Huang; B.J. Cheng; Y. Wan; C. Zhou
08/05/2016
Cervical cancer; Interleukin-10; Polymorphism

We conducted an investigation into the role of the IL-10 polymorphisms -592A/C (rs1800872), -819C/T (rs1800871), and -1082A/G (rs1800896) in cervical cancer risk in a Chinese population. A case-control study was carried out, including 165 newly diagnosed cervical cancer patients and 165 control subjects. The polymerase chain reaction-restriction fragment length polymorphism method ... more

C.Y. Bai; X.Y. Shi; J. He; J. Xue; Y. Feng; C.Y. Bai; X.Y. Shi; J. He; J. Xue; Y. Feng
12/19/2016
Aged; Asian Continental Ancestry Group; Case-control studies; Female; Genetic predisposition to disease; Humans; Interleukin-10; male; Middle Aged; Polymorphism, Single Nucleotide; Regression Analysis; Stomach neoplasms

We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People's Hospital between October 2012 and February 2015. The polymerase chain reaction- ... more

L. Li; X.Y. Tang; L.M. Ye; Q. Yang; Y. Li

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