Research Article

Related GMR Articles

11/22/2013
Biomarker; Mutation; Myelodysplastic syndromes; Refractory cytopenias with multilineage dysplasia; TET2

Myelodysplastic syndrome diagnosis of karyotypically normal patients may be elusive because it relies exclusively on morphological and clinical data. In routine practice, finding of an acquired mutation or a cytogenetic abnormality provides irrefutable evidence of the clonal nature of that disease. Recurrent deletions and somatic mutations in TET2, a gene involved in epigenetic ... more

D.F. Coutinho; C. Diniz; R.L.D. Filgueiras; R.L.R. Baptista; J.P. Ayres-Silva; B.C.R. Monte-Mór; M.H. Bonamino; I.R. Zalcberg
12/29/2015
Biomarker; Diagnosis; Ewing's sarcoma; miR-125; Serum

Previous studies indicated that microRNA-125b (miR-125b) has an important role in the progression of Ewing’s sarcoma (ES). The purpose of the current study was to examine expression changes of miR-125b in the serum of ES patients and evaluate if the expression level of miR-125b could serve as a new biomarker for ES. This study was performed on patients who underwent surgical resection at ... more

C.L. Nie; W.H. Ren; Y. Ma; J.S. Xi; B. Han
12/22/2015
Biomarker; Colorectal cancer; Diagnostic marker; Meta-analysis; MicroRNA-29a

Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based miR-29a for CRC. We performed a ... more

M.L. Zhi; Z.J. Liu; X.Y. Yi; L.J. Zhang; Y.X. Bao
11/30/2015
Biomarker; Matrix-assisted laser desorption ionization-time of flight-mass spectrometry; Primary type I osteoporosis; Proteomics; Weak cation magnetic separation technology

We investigated weak cation magnetic separation technology and matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) in screening serum protein markers of primary type I osteoporosis. We selected 16 postmenopausal women with osteoporosis and nine postmenopausal women as controls to find a new method for screening biomarkers and establishing a ... more

X.L. Shi; C.W. Li; B.C. Liang; K.H. He; X.Y. Li
11/13/2015
Biomarker; Cross-species amplification; Genetic structure; Grey hamster; Microsatellite DNA

The grey hamster has been used in biomedical research for decades. However, effective molecular methods for evaluating the genetic structure of this species are lacking, which hinders its wider usage. In this study, we employed cross-amplification of microsatellite loci of species within the same genus by polymerase chain reaction. Loci screened included 107 from the Mongolian gerbil (MG ... more

C. Wang; S.J. Zhang; X.Y. Du; Y.M. Xu; X.Y. Huo; L.F. Liao; Z.W. Chen
04/04/2016
Biomarker; Breast cancer; Histological subtypes; Proteomics

Breast cancer is the second most common cancer worldwide and the first among women. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological subtypes, and the clinical and molecular differences between them justify the search for new markers to distinguish them. As proteomic analysis allows for a powerful and analytical approach to identify ... more

N.C.S. Oliveira; T.H.B. Gomig; H.H. Milioli; F. Cordeiro; G.G. Costa; C.A. Urban; R.S. Lima; I.J. Cavalli; E.M.S.F. Ribeiro; N.C.S. Oliveira; T.H.B. Gomig; H.H. Milioli; F. Cordeiro; G.G. Costa; C.A. Urban; R.S. Lima; I.J. Cavalli; E.M.S.F. Ribeiro; N.C.S. Oliveira; T.H.B. Gomig; H.H. Milioli; F. Cordeiro; G.G. Costa; C.A. Urban; R.S. Lima; I.J. Cavalli; E.M.S.F. Ribeiro
10/24/2016
Biomarker; Env; Gag; HIV; Molecular epidemiology; Pol

HIV genotyping has led to conflicting results between laboratories. Therefore, identifying the most accurate gene combinations to sequence remains a priority. Datasets of Chinese HIV subtypes based on several markers and deposited in PubMed, Metstr, CNKI, and VIP databases between 2000 and 2015 were studied. In total, 9177 cases of amplification-positive samples ... more

L. Ren; H.W. Wang; Y. Xu; Y. Feng; H.F. Zhang; K.H. Wang
09/28/2015
ATP; ImmuKnow assay; Prognosis; Renal carcinoma

This study aimed to explore the clinical value of the CD4+ T cell ATP levels in patients with renal cell carcinoma through the application of the ImmuKnowTM-Cylex® assay. We recruited 104 patients with renal cancer who had undergone surgery at Fuzhou General Hospital from March 2009 to June 2012, and were subsequently treated by dendritic cell and ... more

K. Zheng; J.P. Zhang; J.M. Tan; W.Z. Wu; S.L. Yang; D.D. Ke
09/01/2015
Acute carbon monoxide poisoning; Copeptin; Ischemiamodified albumin; Prognosis

This study evaluated the relationships among copeptin, ischemia-modified albumin (IMA), and extent of myocardial injury in patients with acute carbon monoxide poisoning (ACOP). A total of 110 patients with different degrees of ACOP were selected as the poisoning group, and 30 healthy individuals as the control group. The levels of troponin I (cTnI), IMA, and copeptin were detected. Based on ... more

J. Li; J.S. Wang; Z.X. Xie; W.Z. Wang; L. Wang; G.Y. Ma; Y.Q. Li; P. Wang
07/31/2015
Cervical carcinoma; FasL; Ki67; Prognosis

This study aimed to investigate the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma and to explore the biological processes and signal pathways related to cervical carcinoma. Cervical carcinoma tissue specimens from 200 patients and normal tissue specimens adjacent to lesions from 30 cases were collected in this study. Ki67 and FasL proteins in ... more

S.N. Liang; Y.J. Huang; L.L. Liu; X. Liu

Pages