Research Article

Related GMR Articles

Interleukin 21; Meta-analysis; Polymorphism; Systemic lupus erythematosus

Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the ... more

J.H. Qi; J. Qi; L.N. Xiang; G. Nie
Ahr; Breast cancer; Gene; Meta-analysis; Polymorphism

Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer. The protocol was approved by ... more

Y. Li; H.Z. Qin; Q. Song; X.D. Wu; J.H. Zhu
Apoptosis; C-33A; Caspase; Cervical cancer; FoxO1; TNF-α

Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer. In our study, we used the well- ... more

B. Zhang; L. Gui; L. Zhu; X. Zhao; Y. Yang; Q. Li
Autoimmune disease; CTLA-4; PTPN22; TNF-α; Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polyglandular syndrome type III (APSIII); ... more

N.A.C. Tavares; M.M.S. Santos; R. Moura; J. Araújo; R.L. Guimarães; S. Crovella; L.A.C. Brandão
IL-6; miR-31; NF-κB; Peripheral blood mononuclear cells; TNF-α; Tuberculosis

We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People’s Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in ... more

J.X. Wang; J. Xu; Y.F. Han; Y.B. Zhu; W.J. Zhang
Celiac disease; HLA-DQ; IL-6; TNF-α

The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibility to CD. A case-control of 192 patients ... more

R.Mde Albuque Maranhão; F.A.Martins Esteves; S. Crovella; L. Segat; P.R.Eleutério Souza
Glioma invasiveness; Heat shock factor-1; HSF1; Thermotherapy; TNF-α; Tumor necrosis factor-α

Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry were used to investigate the levels of TNF-α mRNA and heat shock ... more

L.J. Qin; T. Zhang; Y.S. Jia; Y.B. Zhang; Y.X. Zhang; H.T. Wang
BRL-3A cells; Connexin 32; Gap junction; Oleamide; siRNA; TNF-α

The aim of this study was to observe the influence of gap junction (GJ) functional changes on the hepatotoxicity of TNF-α. Three different methods were employed to study functional effects of the GJ inhibition: 1) pretreatment with a GJ inhibitor; 2) inoculation of cells at high and low densities; and 3) inhibition of the expression of connexin 32 (Cx32) by small inhibitory RNA ... more

Z.Y. Chen; R. Wang; F. Huang; D.D. Yuan; S.R. Li
IL-6; Immunohistochemistry; Invasive pituitary adenomas; TNF-α

The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found to be upregulated in IPA tissue compared with that ... more

J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan
Endostatin; MDAMB 231; TNF-α; TRAIL; Vinorelbine

Surgery, chemotherapy and radiotherapy, which are known as conventional cancer treatments, have been applied for more than 40 years. Because the target of chemotherapy is tumor cells, treatment agents are used at high doses during application and this creates toxic responses, causing side effects in normal cells. Furthermore, due to the high doses, cancer cells ... more

C. Kilit; E.A. Aydemir; K. Fiskin