Research Article

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10/26/2015
-174 G/C; Gene polymorphism; IL-6; Ischemic stroke

Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were ... more

X.F. Jin; D.L. Wang; Y. Zhou; H. Xiong
12/17/2015
IL-6; miR-31; NF-κB; Peripheral blood mononuclear cells; TNF-α; Tuberculosis

We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People’s Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in ... more

J.X. Wang; J. Xu; Y.F. Han; Y.B. Zhu; W.J. Zhang
03/22/2016
IL-6; Immunohistochemistry; Invasive pituitary adenomas; TNF-α

The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found to be upregulated in IPA tissue compared with that ... more

J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan
10/27/2015
Celiac disease; IL2/IL21; Meta-analysis; SH2B3; Single nucleotide polymorphisms

Celiac disease (CD) is a common autoimmune disorder characterized by heightened immunological response to ingested gluten. Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear. We performed a meta-analysis of the associations between rs6822844, rs6840978, and ... more

C.C. Guo; W.H. Huang; N. Zhang; F. Dong; L.P. Jing; Y. Liu; X.G. Ye; D. Xiao; M.L. Ou; B.H. Zhang; M. Wang; W.K. Liang; G. Yang; C.X. Jing
07/06/2015
Apoptosis; C-33A; Caspase; Cervical cancer; FoxO1; TNF-α

Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer. In our study, we used the well- ... more

B. Zhang; L. Gui; L. Zhu; X. Zhao; Y. Yang; Q. Li
12/28/2015
Autoimmune disease; CTLA-4; PTPN22; TNF-α; Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polyglandular syndrome type III (APSIII); ... more

N.A.C. Tavares; M.M.S. Santos; R. Moura; J. Araújo; R.L. Guimarães; S. Crovella; L.A.C. Brandão
12/07/2015
Meta-analysis; Polymorphism; TNF-α; Urogenital cancer

We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the ... more

J. Cai; M.Y. Yang; N. Hou; X. Li
10/02/2015
Glioma invasiveness; Heat shock factor-1; HSF1; Thermotherapy; TNF-α; Tumor necrosis factor-α

Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry were used to investigate the levels of TNF-α mRNA and heat shock ... more

L.J. Qin; T. Zhang; Y.S. Jia; Y.B. Zhang; Y.X. Zhang; H.T. Wang
10/05/2015
BRL-3A cells; Connexin 32; Gap junction; Oleamide; siRNA; TNF-α

The aim of this study was to observe the influence of gap junction (GJ) functional changes on the hepatotoxicity of TNF-α. Three different methods were employed to study functional effects of the GJ inhibition: 1) pretreatment with a GJ inhibitor; 2) inoculation of cells at high and low densities; and 3) inhibition of the expression of connexin 32 (Cx32) by small inhibitory RNA ... more

Z.Y. Chen; R. Wang; F. Huang; D.D. Yuan; S.R. Li
03/30/2020
Endostatin; MDAMB 231; TNF-α; TRAIL; Vinorelbine

Surgery, chemotherapy and radiotherapy, which are known as conventional cancer treatments, have been applied for more than 40 years. Because the target of chemotherapy is tumor cells, treatment agents are used at high doses during application and this creates toxic responses, causing side effects in normal cells. Furthermore, due to the high doses, cancer cells ... more

C. Kilit; E.A. Aydemir; K. Fiskin

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