Research Article

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07/17/2015
Hcy; Methylation; MTHFR; Pregnancy hypertension

We investigated the correlation between 5,10-methy­lenetetrahydrofolate reductase (MTHFR) gene methylation and pre-eclampsia, and its clinical significance, by comparing methylation in the MTHFR gene promoter of the placenta and peripheral venous blood in pre-eclampsia and normal gravidas. We enrolled 259 gravidas from the People’s Liberation Army 202nd Hospital, China, between ... more

J. Ge; J. Wang; F. Zhang; B. Diao; Z.F. Song; L.L. Shan; W. Wang; H.J. Cao; X.Q. Li
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Head and neck cancer; MTHFR; Radiotherapy

The C677T and A1298C polymorphisms in methylene­tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous cell carcinoma (HNSCC) may respond ... more

Q.S. Anders; E. Stur; L.P. Agostini; F.M. Garcia; R.S. Reis; J.A. Santos; S.O. Mendes; L.L. Maia; G.T. Peterle; V. Stange; M.B. Carvalho; E.H. Tajara; M. Santos; A.M.A. Silva-Conforti; I.D. Louro
08/28/2015
Breast cancer; Glutathione S-transferases; Polymorphism

The current study aimed at evaluating the associa­tion between GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms and clinical response to chemotherapy and treatment outcome of breast cancers patients. Genotyping of GSTP1 rs1695, GSTT1 deletion, and GSTM1 deletion was performed by Polymerase Chain Reaction Restriction Fragment Length Polymor­phism (PCR-RFLP) assay. ... more

X. Wang; Z.H. Huang
12/14/2015
Breast cancer; KRAS; let-7; Polymorphism

Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, ... more

X. Huang; Y. Yang; Y. Guo; Z.L. Cao; Z.W. Cui; T.C. Hu; L.B. Gao
12/11/2015
Breast cancer; Chemotherapy; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment ... more

P. Yuan; L. Yuan; B.L. Xu; C.Z. Wang; H.Z. Yang; Y. Li
11/25/2015
Angiotensin II type-1 receptor; Breast cancer; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through ... more

L. Li; F. Wang; P.W. Lv; M.Z. Zhu; J.J. He; G.C. Guo; Y.T. Gu; M.L. Han
05/17/2006
C677T polymorphism; Colorectal cancer; Hypermethylation; Methylenetetrahydrofolate reductase; Microsatellite instability; MTHFR

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Considering that methylation abnormalities appear to be important for the ... more

A.D. Clarizia; L. Bastos-Rodrigues; H.B. Pena; C. Anacleto; B. Rossi; A. Lopes; J.Cláudio C. Rocha; O. Caballero; A. Camargo; A.J.G. Simpson; S.D.J. Pena; F.A. Soares
12/14/2011
Colorectal cancer risk; Genotype; Haplotype; MTHFR

Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C ... more

H. Li; W.L. Xu; H.L. Shen; Q.Y. Chen; L.L. Hui; L.L. Long; X.L. Zhu
06/21/2011
Colorectal cancer; Kashmir; MTHFR; Polymorphism; Restriction digestion; RFLP

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been ... more

A.S. Sameer; Z.A. Shah; S. Nissar; S. Mudassar; M.A. Siddiqi
06/22/2010
C677T polymorphism; Folate; Homocysteine; MTHFR; Vitamin B12

Association between neural tube defects (NTDs) and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was suspected, because the MTHFR gene codes for a key enzyme in folate metabolism. Its deficiency usually leads to significant reductions in plasma concentrations of folate, vitamin B12 and methionine, whereas homocysteine levels are increased. We ... more

M.O. Erdogan; S.H. Yildiz; M. Solak; O. Eser; E. Cosar; B. Eser; R. Koken; S. Buyukbas

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