Research Article

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10/26/2010
ACE gene; GSTM1; GSTT1; Polymorphism; Retinopathy of prematurity

One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of the ACE gene. Glutathione-S-transferase enzyme (GST) is one of ... more

M. Yildiz; M. Karkucak; T. Yakut; O. Gorukmez; A. Ozmen
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Endometriosis; GSTM1; GSTT1; Infertility

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of ... more

A.B. Frare; A.M. Barbosa; I.R. Costa; S.R. Souza; R.C.P.C. Silva; B.M. Bordin; C.L.Ribeiro Júnior; K.K.V.O. Moura
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Glaucoma; Glutathione S-transferase; GSTM1; GSTT1

In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based ... more

C.T.X. Silva; N.B. Costa; K.S.F. Silva; R.E. Silva; K.K.V.O. Moura
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GSTM1; GSTT1; Preeclampsia

Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutathione S-transferases (GST) M1 and T1 genes and the risk of ... more

A. Sandoval-Carrillo; M. Aguilar-Duran; F. Vázquez-Alaniz; F.X. Castellanos-Juárez; M. Barraza-Salas; E. Sierra-Campos; A. Téllez-Valencia; O. La Llave-León; J.M. Salas-Pacheco
06/30/2007
Assisted human reproduction; AZF; Male infertility; Y microdeletions

Microdeletions in Yq are associated with defects in spermatogenesis, while those in the AZF region are considered critical for germ cell development. We examined microdeletions in the Y chromosomes of patients attended at the Laboratory of Human Reproduction of the Clinical Hospital of the Federal University of Goiás as part of a screening of patients who plan to undergo assisted ... more

J.T. Arruda; B.M. Bordin; P.R. Santos; W.E.J.C. Mesquita; R.C.P.C. Silva; M.C.S. Maia; M.S. Approbato; R.S. Florêncio; W.N. Amaral; M.A.Rocha Filho; K.K.V.O. Moura
11/24/2009
Androgen receptor; AR gene; Male infertility; Spermatogenesis; Teratozoospermia

The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), ... more

W.E.J.C. Mesquita; M.S. Approbato; K.K.V.O. Moura; R.S.A. Jesuíno
08/04/2009
Azoospermia; Chromosomal abnormality; Male infertility; Severe oligozoospermia; Y chromosome microdeletion

Infertility is defined as the inability to conceive a child after one year of regular unprotected intercourse; it is a major health problem affecting about 10-15% of all couples. Infertility is due to a male factor in approximately 50% of cases. The human Y chromosome contains genes necessary for gonadal differentiation into a testis and genes for complete spermatogenesis. We examined the ... more

G.G. Ceylan; C. Ceylan; H. Elyas
07/08/2008
Male infertility; vertical transmission; Y chromosome

Male infertility is considered to be a difficult-to-treat condition because it is not a single entity, but rather reflects a variety of different pathologic conditions, thus making it difficult to use a single treatment strategy. Structural alterations in the Y chromosome have been the principal factor responsible for male infertility. We examined 26 family members of 13 patients with male ... more

R.G. Rodovalho; J.T. Arruda; K.K.V.O. Moura
06/29/2010
AZF regions; Male infertility; STS markers; Y-chromosome microdeletion

Infertility is a major reproductive health threat; the frequency of male infertility due to Y-chromosome microdeletions is 13-18% in the human population; these microdeletions involve recurrent loss of three non-overlapping regions designated as AZFa, AZFb and AZFc, associated with spermatogenic failure. Several contradictory reports have been published regarding deletion frequency based ... more

L.K. Pandey; S. Pandey; J. Gupta; A.K. Saxena
04/06/2010
Familial Mediterranean fever; Male infertility; Mediterranean fever gene

Male infertility is a common barrier that prevents successful conception. There have been reports of azoospermia in men with familial Mediterranean fever, some of whom had not been treated with colchicine. Variation in this disorder could be a risk factor for amyloidosis associated with azoospermia. We determined the frequency of 6 of the most common Mediterranean fever gene mutations, ... more

E.O. Etem; D. Erol; Y. Huseyin; A. Arslan

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