Research Article

Related GMR Articles

11/23/2015
Genetic susceptibility; HLA; Leishmaniasis

Leishmaniasis is a parasitic infectious disease with global repercussions. American cutaneous leishmaniasis (ACL) is endemic in southern Brazil and its pathogenesis varies according to parasite species, immune response, and host genetics. In terms of immunogenetics, many host genes, including HLA (human leukocyte antigen), could be involved in susceptibility to and protection against ACL ... more

R.C. Ribas-Silva; A.D. Ribas; E.C. Ferreira; T.G.V. Silveira; S.D. Borelli
08/03/2015
Diabetes mellitus; Genetic susceptibility; Melatonin receptor; MT2; Pregnancy; Single nucleotide polymorphisms

We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were detected by DNA ... more

Y. Zhan; C. Li; Q. Gao; J. Chen; S. Yu; S.G. Liu
10/21/2015
DNMT3B -149C/T polymorphism; Genetic susceptibility; LSCC; Risk

A variety of molecular epidemiological studies have been conducted to examine the association between the DNMT3B -149C/T polymorphism and cancer susceptibility; however, there has been no study investigating the association between the DNMT3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma (LSCC) until now. To determine the role of the DNMT3B ... more

X.M. Zhang; S. Li; Q.M. Zhang
07/26/2019
-174G>C; Adult-onset T1D; Asp358Ala; Genetic susceptibility; IL6R; Promoter polymorphism

Type 1 Diabetes mellitus (T1D) is caused by the immune-mediated destruction of insulin-producing islet β cells, and its pathogenesis involves cytokines. Genetic background may influence cytokine signals, and polymorphisms may determine their impact on T1D autoimmunity. Several polymorphisms in and close to Interleukin-6 (IL-6) and Interleukin-6 Receptor ( ... more

L.P. Campos; V. Graciolo; M.M. Sousa; B.R. Martins; S.W. Souza; D. Alberton; G. Picheth; F.G.M. Rego
08/20/2019
Genetic susceptibility; Polymorphism; Protein tyrosine kinase 2; SNP; Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1D) is considered a polygenic disease that is influenced by environmental factors and autoimmune responses to autoantibodies, resulting in metabolic abnormalities. Tyrosine kinase 2 (TYK2) is involved in type I interferon signaling in beta cells, and TYK2 polymorphism rs2304256 has been associated with T1D. We ... more

V. Graciolo; M. Welter; L.P. Campos; B.R. Martins; S.W. Souza; S.N. França; R.R. Réa; G. Picheth; F.G.M. Rego
01/31/2022
Brazilian population; Genetic epidemiology; Genetic susceptibility; Polymorphisms; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a chronic, complex, multifactorial and polygenic disease, constituting one of the greatest public health challenges worldwide. The genetic background has been shown to strongly influence the disease’s susceptibility. We performed genetic screening of risk-variants for T2DM and complications in the Brazilian population. This ... more

J.S. Campos; K.F. Santos; C.C.P. Costa; J.B.S. Barros; V.S.S. Gonçalves; L.P. Assunção; A.A.S. Reis; R.S. Santos
12/29/2015
Cervical cancer; COMT; CYP1A1; Gene polymorphism

The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were analyzed: a) 81 ... more

J.P. Kleine; C.M. Camargo-Kosugi; C.V. Carvalho; F.C. Silva; I.D.C.G. Silva
05/25/2016
CYP1A1; Estrogen receptor β; GSTM1; GSTT1; p53; Progesterone receptor

In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response ... more

K.S.F. Silva; K.K.V.O. Moura; K.S.F. Silva; K.K.V.O. Moura
05/23/2016
CYP1A1; Meta-analysis; Oral cancer; Polymorphism

Numerous studies regarding the association between the CYP1A1 MspI polymorphism and oral cancer risk in Asian populations have shown controversial results. To get a more precise estimation of this relationship, we conducted a comprehensive meta-analysis. PubMed, the Cochrane Library, Elsevier Science Direct, Web of Knowledge, the Chinese National Knowledge Infrastructure, VIP, ... more

J.L. Xu; R. Xia; L. Sun; X. Min; Z.H. Sun; C. Liu; H. Zhang; Y.M. Zhu; J.L. Xu; R. Xia; L. Sun; X. Min; Z.H. Sun; C. Liu; H. Zhang; Y.M. Zhu
12/09/2015
Genotype; Hepatitis B virus; Sequence analysis

Hepatitis B virus genotype C (HBV/C) has the largest number of subgenotypes (C1-C16) that vary with geography and isolates. HBV/C prevails in Southeast Asia (C1, C5-C16), East Asia (C2), Oceania (C3), and Australia (C4). Suitable reference strains for different subgenotypes could greatly facilitate research into HBV/C, but unfortunately they are scarce. We retrieved 974 HBV/C full-length ... more

H.L. Zhu; C.T. Wang; J.B. Xia; X. Li; Z.H. Zhang

Pages