Research Article

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12/28/2015
Invasion; MiR-874; Osteosarcoma; Prognosis; Proliferation

Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The expression level of miR-874 was ... more

L.Q. Zhang; S.L. Sun; W.Y. Li; Z. Feng; X.Y. Xu; Q.S. Zhuang; J. Fang
07/03/2015
MAFK; Osteosarcoma; Proliferation; Wnt

Osteosarcoma is one of the most common primary bone tumors in children and young adults. In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related osteosarcoma development. We first reported that MAFK was expressed at low ... more

R. Wang; J. Zheng; D.S. Zhang; Y.H. Yang; Z.F. Zhao
11/13/2015
Invasion; miR-184; Osteosarcoma; Proliferation

Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expressed in multiple tumors, and is ... more

G.R. Yin; Q. Wang; X.B. Zhang; S.J. Wang
03/28/2016
BANCR; Invasion; Long noncoding RNA; Osteosarcoma; Prognosis
Z.Q. Peng; R.B. Lu; D.M. Xiao; Z.M. Xiao; Z.Q. Peng; R.B. Lu; D.M. Xiao; Z.M. Xiao
09/21/2015
Breast cancer; GIT2; Metastasis; MTERF; Multiplex RT-PCR

Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive markers for metastatic risk. This multiplex ... more

S. Sirirattanakul; P. Wannakrairot; T. Tencomnao; R. Santiyanont
09/21/2015
EGFR; FISH; Metastasis; NSCLC

The aim of this study was to explore epidermal growth factor receptor (EGFR) gene amplification and its relationship with cancer invasion and metastasis in non-small cell lung cancer (NSCLC). EGFR amplification in 45 patients with NSCLC and 15 subjects with normal lung tissues was detected by fluorescence in situ hybridization. The relationship between EGFR ... more

X.F. Jia; J. Li; H.B. Zhao; J. Liu; J.J. Liu
12/16/2015
Bcl-2; Cervical cancer; KAI1; Metastasis; Survivin

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation with metastasis in cervical ... more

X.L. Zhou; M. Wang
12/08/2015
Metastasis; Neuroblastoma; Neuron-specific enolase; Nude mice; Xenograft

The aim of this study was to establish a metastatic human neuroblastoma (NB) mouse model by xenograft in order to study the metastatic mechanisms of NB. A human NB cell line was obtained from a 5-year-old patient and cultured in vitro. A suspension of these cells was subcutaneously inoculated into nude mice at the right flank next to the forelimb. The biological characteristics of the ... more

Q. Gao; C.F. Chen; Q. Dong; L. Hou; X. Chen; Y.L. Zhi; X. Li; H.T. Lu; H.Y. Zhang
12/08/2015
Chemical treatment; Dendritic cells; Immune treatment; Liver; Metastasis; Recurrence

We aimed to evaluate dendritic cell (DC) tumor vaccines for preventing liver cancer recurrence and metastasis. DCs were induced from mononuclear cells in the peripheral blood with recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) and recombinant human interleukin 4 (rhIL-4), followed by sensitization with lysis of autologous liver cancer cells. One hundred and ... more

T.Y. Sun; W. Yan; C.M. Yang; L.F. Zhang; H.L. Tang; Y. Chen; H.X. Hu; X. Wei
12/02/2015
CapG; Cell growth; Invasion; Metastasis; Prostate cancer; RNA interference

This study investigated CapG gene expression in prostate cancer cell lines; in addition, we explored the effects of CapG suppression on DU145 cell growth, and the underlying mechanism with which CapG affects DU145 cell growth and invasiveness. The expression of CapG and 18 related genes in DU145 cells was analyzed by flow cytometry, quantitative polymerase chain reaction (qPCR), ... more

B.K. Li; K. Guo; C.Y. Li; H.L. Li; P.P. Zhao; K. Chen; C.X. Liu

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