Research Article

Related GMR Articles

12/17/2015
Meta-analysis; Polymorphism; Tumor necrosis factor-α; Vitiligo

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the ... more

G. Nie; J.H. Qi; C.W. Huang; T. Yang; N. Shi; Y.J. Chen
12/17/2015
Meta-analysis; NAT2; Pancreatic cancer; Polymorphism; susceptibility

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to assess this relationship ... more

J.X. Liang; W. Gao; Y. Liang; X.M. Zhou
12/02/2015
Case-control study; Crohn’s disease; Meta-analysis; Polymorphism; Tumor necrosis factor-α

We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn’s disease (CD) using a meta-analysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search in October 2014) were comprehensively searched for relevant ... more

Y.Q. Mao; S.Q. Dong; M. Gao
11/30/2015
Alcohol dehydrogenase 1C; Meta-analysis; Pancreatitis risk; Polymorphism

Numerous studies have focused on the relationship be­tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal­ysis to more precisely estimate this association. Relevant publications were searched in several widely used ... more

F. Fang; J. Pan; G.H. Su; L.X. Xu; G. Li; Z.H. Li; H. Zhao; J. Wang
11/25/2015
Angiotensin II type-1 receptor; Breast cancer; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through ... more

L. Li; F. Wang; P.W. Lv; M.Z. Zhu; J.J. He; G.C. Guo; Y.T. Gu; M.L. Han
11/23/2015
Colorectal cancer; Meta-analysis; Polymorphism; XRCC3

Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 T241M polymorphism and CRC risk. The PubMed and Embase ... more

L.Z. Zhang; Y.S. Li; H.Z. Liu
11/23/2015
Gastric cancer; hOGG1 gene; Meta-analysis; Polymorphism; Risk association study

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address ... more

W.G. Hu; R.J. Pan; W. Cai; Z.T. Wang; Z.G. Zhu
11/19/2015
Meta-analysis; Polymorphism; Psoriasis; Vascular endothelial growth factor

The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibil­ity to psoriasis. Meta-analyses were conducted to examine the asso­ciations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and reces­sive, dominant, and additive models. Seven studies ... more

Y.H. Lee; G.G. Song
10/30/2015
Cancer; Meta-analysis; Polymorphism; Vascular endothelial growth factor

The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched ... more

J.Y. Ban; J.I. Shin; C.H. Oh
10/21/2015
A-20C; Angiotensinogen gene; Essential hypertension; Meta-analysis; Polymorphism

The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved from PubMed. ... more

R. Zeng; Q.P. Wang; M.X. Fang; J. Zhuang; R.X. Fan

Pages