Research Article

Related GMR Articles

08/03/2015
Bcl-2; Hypoxic ischemic brain injury; IL-18; Montelukast; Rat brain tissue; TERT

The aim of this study was to investigate the effect of mon­telukast on the expression of interleukin (IL)-18, telomerase reverse tran­scriptase (TERT), and Bcl-2 in the brain tissue of neonatal rats with hypox­ic-ischemic brain damage (HIBD). To establish the model of HIBD, 8% oxygen was applied to rats after the unilateral carotid artery was ligated. Twenty rats were randomly assigned ... more

J.L. Liu; X.H. Zhao; D.L. Zhang; J.B. Zhang; Z.H. Liu
01/22/2016
IL-18; Meta-analysis; Polymorphism; Rheumatoid arthritis

Interleukin-18 (IL-18), an important proinflammatory cytokine, has been reported to play a potential pathological role in rheumatoid arthritis (RA). Results from previous studies on the association between IL-18 polymorphisms and RA are conflicting. To clarify this, an updated meta-analysis of all available studies on IL-18 polymorphisms and RA was conducted. Eligible articles were ... more

L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen; L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen; L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen
08/26/2016
Acute pancreatitis; Chinese population; IL-18; Polymorphism

We investigate the relationship between IL-18 -607C/A and -137G/C genetic polymorphisms and development of acute pancreatitis in a Chinese population. A total of 153 patients were consecutively recruited from the First Affiliated Hospital of Chongqing Medical University between January 2013 and November 2014. Genotyping of IL-18 -607C/A and -137G/C variants was performed ... more

H.B. Gui; X.G. Du; Z.H. Fu; X.M. Chen; H.B. Gui; X.G. Du; Z.H. Fu; X.M. Chen
07/29/2016
Cytokines; IL-18; IL-4; Non-Hodgkin’s lymphoma

Strong evidence indicates that tumor growth can be actively controlled by the immune system, and interleukins (ILs) are known to play an influential role in immune response regulation. Moreover, inflammatory cytokines are significantly involved in lymphoma pathogenesis. We aimed to investigate serum levels of IL-4 and IL-18 in aggressive non-Hodgkin’s lymphoma (A-NHL) patients and their ... more

H.O. Soydinc; N. Guney; M. Basaran; D. Duranyildiz; V. Yasasever; H.O. Soydinc; N. Guney; M. Basaran; D. Duranyildiz; V. Yasasever
10/24/2016
-372C/G; -607A/C; Coronary artery disease; IL-18; Polymorphism

Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were ... more

J.B. Ma; L. Chen; B. Gao; J. Xu
11/30/2020
Adult-onset T1DM; Case-control study; Childhood-onset T1DM; IL-18; Polymorphisms; PTPN22

Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic β-cells. Interleukins such as interleukin 18 (IL-18) and protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) have been found to be associated with immune related diseases. We investigated a possible association of polymorphisms in IL-18 gene rs1946518 and ... more

L.P. Campos; V. Graciolo; M. Welter; M.S. Lopes; S. Nesi-França; G. Picheth; F.G.M. Rego