Research Article

Related GMR Articles

12/17/2015
IL-6; miR-31; NF-κB; Peripheral blood mononuclear cells; TNF-α; Tuberculosis

We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People’s Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in ... more

J.X. Wang; J. Xu; Y.F. Han; Y.B. Zhu; W.J. Zhang
12/03/2015
Human leukocyte antigen-DRB1; Meta-analysis; Tuberculosis

Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association ... more

B.F. Chen; R. Wang; Y.J. Chen; Y. Zhu; L. Ding; Y.F. Wen
05/13/2016
Diabetic retinopathy; Inflammatory cytokines; Ozone treatment; VEGF

The aim of this study was to investigate the effect of ozone on inflammatory cytokines in diabetic retinopathy (DR) rats. Male rats (40) weighing 300-360 g were included in this study. Thirty rats were randomly divided into the model and ozone groups after DR was induced by streptozotocin. Ten rats served as the blank group. After the diabetic models were established for one month, the ... more

T.Y. Xie; W. Yan; J. Lou; X.Y. Chen; T.Y. Xie; W. Yan; J. Lou; X.Y. Chen
03/24/2016
Interferon-gamma; Interleukin-17; Neutrophil; Respiratory syncytial virus

The aim of this study was to observe the effect of interleukin (IL)-17 on early immune response and inflammation in the lungs of respiratory syncytial virus (RSV)-infected mice. Specific pathogen-free BALB/c mice were randomly assigned to control, RSV-infected, RSV-infected with phosphate-buffered saline, and RSV-infected + IL-17 intervention groups. The RSV infection model was set up by ... more

G. Zhang; K.F. Zhou; Z.H. Lu; G. Zhang; K.F. Zhou; Z.H. Lu; G. Zhang; K.F. Zhou; Z.H. Lu
12/19/2016
Aged; Asian Continental Ancestry Group; Carcinoma, Non-Small-Cell Lung; China; Female; Genetic predisposition to disease; Humans; Interferon-gamma; Interleukin-18; Lung Neoplasms; male; Middle Aged; Polymorphism, Single Nucleotide; Tumor necrosis factor-alpha

Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression of interferon-γ and TNF-α in humans. IL18 is therefore involved in ... more

W.Y. Gan; H.M. Li; Y.G. Zhang; C.M. Li; Y. Wang
02/16/2017
Adolescent; Adult; Aged; Case-control studies; Female; Gene frequency; Genetic association studies; Genetic predisposition to disease; Genotype; Humans; Interferon-gamma; Introns; male; Middle Aged; Multiple sclerosis; Polymorphism, Single Nucleotide; Young Adult

The present study aims to examine the relationship between polymorphisms in the third intron of the IFN-γ gene and their influence on susceptibility to multiple sclerosis. A population-based case-control study was used for this purpose. Multiple sclerosis patients and healthy controls were interviewed. Genetic polymorphisms of IFN-γ intron III at the +2118 A/G and +3586 G/ACT sites were ... more

X.L. Wang; F.R. Meng; X. Wang; S.H. Wang; L. Guo
03/16/2017
Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Female; Humans; Interferon-gamma; Interleukin-10; Interleukin-4; male; Prognosis; Severity of Illness Index; Spondylitis, Ankylosing; Th1 Cells; Th2 cells; Tumor necrosis factor-alpha; Young Adult

Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as peripheral arthritis with tendon and ligament inflammation that restricts activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is absent in patients with AS. It is characterized by inflammatory changes such as elevated levels of serum inflammatory factors. The roles of Th1 and Th2 cytokines ... more

J.T. Wen; D.H. Zhang; P.F. Fang; M.H. Li; R.J. Wang; S.H. Li
05/18/2017
Animals; Chickens; Epitopes; Interferon-gamma; Interleukins; Phylogeny; Poultry; Protein Conformation; Toll-Like Receptors

Poultry production is faced with different types of stresses that are responsible for issues of animal welfare as well as for economic losses. Moreover, the immunity decreases when animals are stressed. In silico analyses are important in reducing the cost and in increasing the accuracy of scientific results. A bioinformatics tool was used to perform ontology studies on 15 different ... more

L.J. Lara; A.P. Peconick; É.J. Fassani; A.M.P. Júnior; P.R.B. Chalfun; D.L. Raymundo; T.A. Barçante; J.M. de P. Barçante