Research Article

Related GMR Articles

11/23/2015
Gelatinase; Matrix metalloproteinases; MMP-1; MMP-2; MMP-9; Osteoarthritis

Our study examined the relationship between the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-9 proteins and the pathogenesis of osteoarthritis (OA). We employed rigorous inclusion and exclusion criteria in computer-based bibliographic databases to extract published studies relevant to this investigation. The STATA 12.0 software was used for the statistical analyses. A ... more

G.Q. Zeng; A.B. Chen; W. Li; J.H. Song; C.Y. Gao
04/25/2016
COPD; MMP-1; MMP-3; MMP-9; rs1799750; rs3918242

Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% ... more

S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan; S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan; S. Jiang; Z.H. Yang; Y.Y. Chen; Z. He; Y. Zhou; Y. Gao; Q. Zhang; M.Q. Tan
04/04/2016
Apoptosis; Gastric cancer; miR-451; MMP-2; Proliferation; Propofol

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

Z. Peng; Y. Zhang; Z. Peng; Y. Zhang; Z. Peng; Y. Zhang
07/03/2015
Expression profiles; Ovary; Sheep; MicroRNA; Solexa sequencing

The role of microRNAs (miRNAs) in the regulation of mammalian reproduction has been demonstrated previously. However, only a few studies have assessed the role of miRNAs in the reproduction processes of sheep. The elucidation of miRNA expression profiles in the ovaries of different sheep breeds representing fecundity extremes will be useful in understanding the roles of miRNAs in sheep ... more

H. Shen; H.Y. Chen; B. Jia; G.H. Han; Y.S. Zhang; X.C. Zeng
01/08/2016
Estrous cycle; Frizzled 3; Mouse; Ovary

Frizzled 3 is an important receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes. However, the role of this protein during follicular development in the adult ovary is not known. The present study was designed to investigate the expression and localization of Frizzled 3 mRNA and protein during the ... more

S.B. Wang; Y.P. Liu; Z.H. Zhang; Z.K. Wang; Y.X. Xu; Z.C. Wang; S.B. Wang; Y.P. Liu; Z.H. Zhang; Z.K. Wang; Y.X. Xu; Z.C. Wang; S.B. Wang; Y.P. Liu; Z.H. Zhang; Z.K. Wang; Y.X. Xu; Z.C. Wang
3/22/2017
Animals; Estradiol; Female; Follicle Stimulating Hormone; Geese; Gonadotropin-releasing hormone; Gonadotropins; Hormones; Luteinizing Hormone; Ovary; Photoperiod; Prolactin; Reproduction; Vasoactive Intestinal Peptide

The poor egg-laying rate of geese hinders the development of the goose industry; therefore, the reproductive performance of geese is an important area of investigation. To evaluate the relationship between photoperiod, reproductive hormones, and reproductive activity during the egg-laying cycle in geese under natural conditions, we collected blood samples from Sichuan white geese and Xupu ... more

X.Z. Zhao; G.L. Gao; H.W. Wang; Q. Li; K.S. Zhang; H. Zhong; Q.G. Wang
05/10/2017
Adipose tissue; Animals; Antioxidants; Body weight; Camellia sinensis; Chromosomal Proteins, Non-Histone; Chronotherapy; Circadian rhythm; Diet; Eating; Female; Homeostasis; Lipid metabolism; Liver; Liver X Receptors; Mice; Ovary; Oxidation-Reduction; Plant Extracts; Tea

Biological rhythms can be defined as changes in physiological or behavioral variables that repeat at certain time intervals. Rhythms that last approximately 24 h are referred to as circadian rhythms. Modern lifestyles have drastically affected human habits, as well as the population's eating habits. These changes have generated an epidemic of metabolic syndromes, such as obesity and diabetes. ... more

R.P. Amorim; I.P. Daher; F.P.D. Arcangelo; M.F. Bellini; W.A. Orcini; G.R. Sarria; R.L. Peruquetti