Research Article

Related GMR Articles

12/08/2015
Ahr; Breast cancer; Gene; Meta-analysis; Polymorphism

Published data regarding the association between aryl hydrocarbon receptor (Ahr) rs2066853 polymorphism and the risk of breast cancer shows conflicting results. We performed a meta-analysis on 2999 patients and 3050 controls from three related case-control studies to estimate the association between Ahr rs2066853 polymorphism and the risk of breast cancer. The protocol was approved by ... more

Y. Li; H.Z. Qin; Q. Song; X.D. Wu; J.H. Zhu
12/09/2015
Breast cancer; MTHFR; Polymorphism; Risk

We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length ... more

X.F. Zhang; T. Liu; Y. Li; S. Li
11/25/2015
Angiotensin II type-1 receptor; Breast cancer; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through ... more

L. Li; F. Wang; P.W. Lv; M.Z. Zhu; J.J. He; G.C. Guo; Y.T. Gu; M.L. Han
11/23/2015
BRAF; Breast cancer; KRAS; Mutation; PIK3CA

Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation. Abnormalities in relevant genes play essential roles in the occurrence and development of many human cancers. Studies of breast cancer have mainly focused on the women in western countries, but few studies have examined the frequency of mutations in PIK3CA, BRAF ... more

Y.L. Wang; X. Dai; Y.D. Li; R.X. Cheng; B. Deng; X.X. Geng; H.J. Zhang
10/26/2015
Breast cancer; Chemotherapy response; GSTM1 polymorphism; Mexican population

The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in the mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotypes of 276 ... more

O. Soto-Quintana; G.M. Zúñiga-González; R. Ramírez-Patiño; A. Ramos-Silva; L.E. Figuera; D.I. Carrillo-Moreno; I.A. Gutiérrez-Hurtado; A.M. Puebla-Pérez; B. Sánchez-Llamas; M.P. Gallegos-Arreola
10/27/2015
BRCA1; BRCA2; Breast cancer; Kazakh; mutations

Mutations in the BRCA1/2 genes are associated with an increased risk of breast cancer, but no large-scale research have examined the BRCA1/2 mutations in Chinese Kazakh women. We evaluated the frequency and distributions of BRCA1 and BRCA2 gene mutations in Kazakh sporadic breast cancer patients and healthy women in China. The association between the clinical-pathologic features ... more

S.Y. Yang; D. Aisimutula; H.F. Li; Y. Hu; X. Du; J. Li; M.X. Luan
10/16/2015
Breast cancer; Chinese women; Exome sequencing; SPOP gene

SPOP protein has been found to have ubiquitin ligase activity. Mutations in SPOP gene have been recently reported in some cancers such as prostate, gastric, colorectal cancer. We investigated SPOP DNA mutation in tumor tissues collected from 70 Chinese female breast cancer patients in Southwestern China by DNA sequencing. The results did not show mutation in our tissue samples, indicating ... more

M.A. Khan; L. Zhu; M. Tania; X.L. Xiao; J.J. Fu
02/11/2016
Breast cancer; ILIA; Insertion/deletion; miRNA; Polymorphism

The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically ... more

X. Huang; Y. Yang; Z.W. Cui; J. Wang; L.B. Gao; X. Huang; Y. Yang; Z.W. Cui; J. Wang; L.B. Gao
04/30/2019
Breast cancer; Genetic polymorphism; HLA-G; Saudi Arabia

Human leukocyte antigen-G (HLA-G) has been associated with various immune diseases, including malignancies. The 14-base pair (bp) insertion/deletion (indel) polymorphism (rs16375) in exon 8 of the 3′ untranslated region (3′ UTR) of the HLA-G gene has been reported to influence HLA-G protein expression. We investigated the relationship between the 14-bp indel ... more

S.Y.Al Omar; L. Mansour

Pages