Research Article

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The identification and utilization of potential candidate genes with significant effects on economically important traits have become increasingly important in poultry breeding programs. The prolactin (PRLR) receptor is a specific receptor for prolactin, which is an anterior pituitary peptide hormone involved in various physiological activities and is essential for reproductive success. ... more

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NR5A2 has been implicated in processes as diverse as steroidogenesis, cellular proliferation, ovarian follicular development, ovulation, and fertility in mammals. However, data about the relationship between NR5A2 and prolificacy in mammals are lacking. In the present study, we identified and characterized NR5A2 of Hu sheep, and investigated the correlation ... more

Y.X. Li; J. Zhang; Y. Qian; C.H. Meng; H.L. Wang; X.J. Tao; S. Zhong; S.X. Cao; Q.F. Li
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Gene expression; Hu sheep; Muscle fiber development; MyHCs; YAP1

RT-PCR was used to study the temporal and spatial pattern of Yes-associated protein 1 (YAP1) and myosin heavy chain (MyHC) expression in four different skeletal muscles (i.e., longissimus dorsi muscle, soleus muscle, gastrocnemius muscle, and extensor digitorum longus) and three growth stages (i.e., 2 days old, 2 and 6 months old) of Hu Sheep. The results showed that ... more

W. Gao; W. Sun; R. Su; X.Y. Lv; Q.Z. Wang; D. Li; H.H. Musa; L. Chen; H. Zhou; H.S. Xu; W.H. Hua; W. Gao; W. Sun; R. Su; X.Y. Lv; Q.Z. Wang; D. Li; H.H. Musa; L. Chen; H. Zhou; H.S. Xu; W.H. Hua; W. Gao; W. Sun; R. Su; X.Y. Lv; Q.Z. Wang; D. Li; H.H. Musa; L. Chen; H. Zhou; H.S. Xu; W.H. Hua
05/23/2016
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The mRNA expression levels of key genes (Smads, MSTN, and MyoG) in the TGF-β/Smad signaling pathway in Hu sheep at different growth stages (2 days, 2 months, and 6 months of age) and in different skeletal muscles (longissimus dorsi muscle and soleus muscle) and different genders were detected; and correlation of the Smad family (Smad2 ... more

Q.Z. Wang; R. Su; X.Y. Lv; W. Gao; L. Chen; J.J. Bao; J.R. Yu; L.H. Wang; W. Sun; Q.Z. Wang; R. Su; X.Y. Lv; W. Gao; L. Chen; J.J. Bao; J.R. Yu; L.H. Wang; W. Sun
08/26/2016
Gene expression; Hu sheep; MSTN; Smads; YAP1

The temporal and spatial patterns of Smad and Yes-associated protein 1 (YAP1) expression were investigated in skeletal muscle (gastrocnemius muscle and extensor digitorum longus) at different growth stages (2 days old, 2 and 6 months old) in Hu sheep. Smads were differentially expressed in sheep skeletal muscle, with high expression in the gastrocnemius muscle ... more

W. Gao; R. Su; W. Sun; Q.Z. Wang; X.Y. Lv; J.J. Bao; J.R. Yu; L.H. Wang; H.H. Musa; L. Chen; W. Gao; R. Su; W. Sun; Q.Z. Wang; X.Y. Lv; J.J. Bao; J.R. Yu; L.H. Wang; H.H. Musa; L. Chen
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Hair follicle; Hu sheep; Patterns

The aim of this study was to detect candidate genes for the development of hair follicles in the Hu sheep breed. Seven genes have been detected in large, medium, and small wave follicles of Hu sheep using gene chip technology. The histological features of the follicles of newborn Hu-lambs were combined with fluorescence quantitative PCR technology to detect the correlation between the ... more

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09/22/2015
Body measurement traits; Carcass quality traits; SNP; STAT3

Previous studies have shown that the signal transducer and activator of transcription 3 gene (STAT3) is involved in lipid storage and energy metabolism, suggesting that STAT3 is a potential candidate gene that affects body measurement and carcass quality traits in animals. Therefore, the aim of this study was to identify polymorphisms in bovine STAT3 and to ... more

N. Song; L.S. Gui; H.C. Xu; S. Wu; L.S. Zan
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CRH; Economic traits; Hanwoo; Korean cattle; POMC; SNP

The corticotrophin-releasing hormone (CRH) and proo­piomelanocortin (POMC) genes are considered to play an important role in the growth and development of mammals. In this study, the bovine CRH and POMC genes were characterized to detect genetic variation at these loci in relation to economic traits in Korean cattle (Hanwoo). Nine single ... more

J. Seong; H.S. Kong
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Association study; Schizophrenia; SNP; VRK2 gene

Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 ... more

B. Zhang; C.Y. Gao; H.B. Zhang; B. Yang; J.F. Yin; S.G. Wei; Y.S. Zhu; X.N. Jia; S.B. Li
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COPD; Meta-analysis; rs3795879; SERPINE2; SNP

The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs ... more

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