Research Article

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07/06/2015
Melatonin; Mitochondria; Myocardial ischemia/reperfusion injury

We aimed to evaluate the effect of melatonin on myo­cardial cell oncosis in the myocardial ischemia/reperfusion injury rat, and the role of the mitochondrial permeability transition pore (MPTP) therein. Sprague Dawley rats (N = 60) were randomly divided into five groups of 12 rats each: control, ischemia/reperfusion (I/R), melatonin treatment (MT), melatonin treatment + atractyloside (MT ... more

L.F. Liu; Z.H. Qian; Q. Qin; M. Shi; H. Zhang; X.M. Tao; W.P. Zhu
11/13/2015
Glycolytic potential; meat quality; Mitochondria; Muscle fiber type; Tibetan pigs

The myosin heavy chain (MyHC) composition, glycolytic potential, mitochondrial content, and gene expression related to energy metabolism were analyzed in eight muscles from Tibetan pigs, to study how meat quality develops in different muscle tissues. The muscles were classified into three clusters, based on MyHC composition: masseter, trapezius, and latissimus dorsi ... more

L.Y. Shen; J. Luo; H.G. Lei; Y.Z. Jiang; L. Bai; M.Z. Li; G.Q. Tang; X.W. Li; S.H. Zhang; L. Zhu
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Chloroplast; Genetic relationship; Mitochondria; Nucleus; Prickly pear; Xoconostle

Molecular methods are powerful tools in characterizing and determining relationships between plants. The aim of this study was to study genetic divergence between 103 accessions of Mexican Opuntia. To accomplish this, polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis of three chloroplast intergenic spacers (atpB-rbcL, trnL ... more

S. Samah; E. Valadez-Moctezuma; K.S. Peláez-Luna; S. Morales-Manzano; P. Meza-Carrera; R.C. Cid-Contreras; S. Samah; E. Valadez-Moctezuma; K.S. Peláez-Luna; S. Morales-Manzano; P. Meza-Carrera; R.C. Cid-Contreras
1/23/2017
Animals; Electron Transport Complex IV; Energy metabolism; Mitochondria; Ursidae

The giant panda, Ailuropoda melanoleuca (Ursidae), has a unique bamboo-based diet; however, this low-energy intake has been sufficient to maintain the metabolic processes of this species since the fourth ice age. As mitochondria are the main sites for energy metabolism in animals, the protein-coding genes involved in mitochondrial respiratory chains, particularly cytochrome c oxidase subunit ... more

S.S. Ling; Y. Zhu; D. Lan; D.S. Li; H.Z. Pang; Y. Wang; D.Y. Li; R.P. Wei; H.M. Zhang; C.D. Wang; Y.D. Hu
2/8/2017
Animals; Calcium; Calcium-Binding Proteins; Cation Transport Proteins; Drosophila; Drosophila melanogaster; Gene expression; Locomotion; Mitochondria; Mitochondrial Membrane Transport Proteins; Neurons; Proto-Oncogene Proteins c-bcl-2

The mitochondrial calcium uptake 1 (MICU1) is a regulatory subunit of the mitochondrial calcium uniporter that plays an important role in calcium sensing. It contains two EF-hand domains that are well conserved across diverse species from protozoa to plants and metazoans. The loss of MICU1 function in mammals is attributed to several neurological disorders that involve movement dysfunction. ... more

P.G. M'Angale; B.E. Staveley
09/21/2015
c-Jun N-terminal kinases; CAAT/enhanced I-binding protein; Endoplasmic reticulum stress; Hypertension; Ischemia/reperfusion

Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain ischemia was induced by 4- ... more

Y.N. Zhao; J.M. Li; C.X. Chen; P. Zhang; S.X. Li
08/21/2015
Haplotype; Hypertension; Mongolian; SLC12A3; TagSNP

Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype ... more

J.Q. Liang; Y.G. Xi; C.Y. An; X.L. Su
08/03/2015
Genetics; GWAS; Hypertension; NPR3; Population diversity

Hypertension affects one-fifth of the world population. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that correlated with hyper­tension in large samples. However, the genetic mutations leading to hypertension might differ among various populations, as they have dif­ferent origins and are subjected to different environmental ... more

H. Sun; Z.Q. Yang; S.Y. Liu; L. Yu; K. Huang; K.Q. Lin; J.Y. Chu; X.Q. Huang
12/01/2015
Hypertension; klotho gene; Single nucleotide polymorphism

The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The ... more

L.L. Gao; X. Ding; D.M. Xie; M. Yang; B.R. Dong
11/26/2015
CYP4F2; Gene polymorphism; Hypertension; Meta-analysis

Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the CYP4F2 gene rs2108622 polymorphism and ... more

X.H. Luo; G.R. Li; H.Y. Li

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