Research Article

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12/14/2015
Metastasis; MiR-134; Osteosarcoma; Prognosis; Proliferation

Dysregulation of microRNA (miR) is often associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, its expression and function in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-134 in osteosarcoma tumorigenesis and development. The expression level of miR-134 was quantified by ... more

Y. Bao; L. Peng; J. Ma; K. Liu; W. Li
11/13/2015
Invasion; miR-184; Osteosarcoma; Proliferation

Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expressed in multiple tumors, and is ... more

G.R. Yin; Q. Wang; X.B. Zhang; S.J. Wang
03/28/2016
BANCR; Invasion; Long noncoding RNA; Osteosarcoma; Prognosis
Z.Q. Peng; R.B. Lu; D.M. Xiao; Z.M. Xiao; Z.Q. Peng; R.B. Lu; D.M. Xiao; Z.M. Xiao
12/22/2015
Centrality analysis; Differential expression network; Osteosarcoma; Pathway-enrichment analysis

Despite recent advances in osteosarcoma diagnosis and therapy, much remains unclear about the molecular mechanisms involved in the disorder, and the discovery of novel drug-targeted genes is essential. We explored the potential molecular mechanisms and target genes involved in the development and progression of osteosarcoma. First, we identified the differentially expressed genes in ... more

Y.B. Wang; N. Jia; C.M. Xu; L. Zhao; Y. Zhao; X. Wang; T.H. Jia
07/03/2015
MAFK; Osteosarcoma; Proliferation; Wnt

Osteosarcoma is one of the most common primary bone tumors in children and young adults. In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related osteosarcoma development. We first reported that MAFK was expressed at low ... more

R. Wang; J. Zheng; D.S. Zhang; Y.H. Yang; Z.F. Zhao
07/17/2015
Gastric cancer; Invasion; miR-221; Proliferation; Propofol

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; X.Q. Yue
07/06/2015
Invasion; miR-133a; Pancreatic cancer; Proliferation; Propofol

Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; T.L. Dong
04/04/2016
Apoptosis; Colorectal cancer; Invasion; MiR-874; Prognosis; Proliferation
X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi
03/01/2012
Bone neoplasms; Osteochondroma; Osteosarcoma

Osteochondroma is a cartilage capped benign tumor developing mainly at the juxta-epiphyseal region of long bones. The rate of malignant transformation, mainly into chondrosarcoma, is estimated to be less than 1-3%. Transformation into osteosarcoma is very rare and has been reported only thirteen times. There is little information on treatment and outcome. We report the case of a secondary ... more

E.E. Engel; M.H. Nogueira-Barbosa; M.S. Brassesco; G.E.B. Silva; E.T. Valera; F.M. Peria; T.C. Motta; L.G. Tone
09/28/2015
DNA repair genes; Osteosarcoma; Overall survival; Polymorphism

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed ... more

M.J. Wang; Y. Zhu; X.J. Guo; Z.Z. Tian

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