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The aim of this study was to identify feature genes that are associated with hereditary hemochromatosis (HHC; iron overload) in cardiac and skeletal muscle of mice. First, the expression profile GSE9726 was downloaded from Gene Expression Omnibus database which included 12 samples. Then the differentially expressed genes (DEGs) were identified by R language. Furthermore, the KUPS software ... more

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Body iron overload; European descent; Genetic diseases; Hereditary hemochromatosis; HFE mutations

Hereditary hemochromatosis (HH) is the most common genetic disease among individuals of European descent. Two mutations (845G®A, C282Y and 187C®G, H63D) in the hemochromatosis gene (HFE gene) are associated with HH. About 85-90% of patients of northern European descent with HH are C282Y homozygous. The prevalence of HH in the Brazilian ... more

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