Research Article

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Solute carrier family 13 (sodium-dependent citrate transporter member 5, SLC13A5) gene has been recently found to play an important role in intramuscular fat content in pigs. In this study, the full-length cDNA of porcine SLC13A5 was obtained from the longissimus dorsi muscle of Shaziling pigs, using the rapid amplification of cDNA ends technique. Full-length porcine ... more

L.Y. Wang; J. Jiang; H.M. Ma
12/01/2015
Hypertension; klotho gene; Single nucleotide polymorphism

The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The ... more

L.L. Gao; X. Ding; D.M. Xie; M. Yang; B.R. Dong
10/30/2015
Han Chinese population; Rheumatoid arthritis; Sequencing; Sialic acid acetylesterase; Single nucleotide polymorphism

The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal controls. The coding regions ... more

D.D. Zhang; F. He; H.T. Liu; F. Hao; J. Zhu
10/21/2015
CRTC2; Growth traits; Meat quality traits; Qinchuan cattle; Single nucleotide polymorphism

Growth and meat quality traits play important roles in the evaluation of cattle productivity and are influenced by genetic and environmental factors. CRTC2 is a recently discovered gene related to obesity that may influence fat deposition. The aim of the current study was to detect polymorphisms of bovine CRTC2 and explore their relationships to growth and meat quality ... more

H.C. Xu; L.S. Gui; N. Song; Y.Y. Zhang; H. .C.Wang; L.S. Zan
10/19/2015
Hu sheep; mRNA expression; NR5A2; Reproductive performance; Single nucleotide polymorphism

NR5A2 has been implicated in processes as diverse as steroidogenesis, cellular proliferation, ovarian follicular development, ovulation, and fertility in mammals. However, data about the relationship between NR5A2 and prolificacy in mammals are lacking. In the present study, we identified and characterized NR5A2 of Hu sheep, and investigated the correlation ... more

Y.X. Li; J. Zhang; Y. Qian; C.H. Meng; H.L. Wang; X.J. Tao; S. Zhong; S.X. Cao; Q.F. Li
10/21/2015
Cyprinus carpio var. Jian; Elovl5; Growth trait; Single nucleotide polymorphism; Δ6-desaturase

Highly unsaturated fatty acids (HUFAs) are crucial for the nutritional health, physiology, and reproduction of vertebrates. The Δ6-desaturase and Elovl5 elongase genes produce essential enzymes in the biosynthetic pathway of HUFAs. Single nucleotide polymorphism (SNP) analysis of genes functionally related to the growth traits of the common carp (Cyprinus carpio var. Jian) can ... more

H. .Ren; J. Yu; P. Xu; Y. Tang
10/09/2015
Chronic periodontitis; Single nucleotide polymorphism; Vitamin D receptor

The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 controls. ... more

X. Wang; T.L. Zhang; D. Chen
10/09/2015
Cervical cancer; IL-17A; IL-17F; Interleukin-17A; Interleukin-17F; Single nucleotide polymorphism

We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs2275913, rs3748067, and rs3819025) and IL-17F (rs763780, ... more

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02/11/2016
ABCG2; Gout; PDK2; Metabolic phenotypes; Single nucleotide polymorphism

Previous studies have shown that the PDK2 and ABCG2 genes play important roles in many aspects of gout development in European populations. However, a detailed genotype-phenotype analysis was not performed. The aim of the present study was to investigate the potential association between variants in these two genes and metabolism-related quantitative phenotypes relevant ... more

Y.C. Ren; T.B. Jin; X.D. Sun; T.T. Geng; M.X. Zhang; L. Wang; T. Feng; L.L. Kang; C. Chen; Y.C. Ren; T.B. Jin; X.D. Sun; T.T. Geng; M.X. Zhang; L. Wang; T. Feng; L.L. Kang; C. Chen
10/17/2016
Admixed population; African ancestry; Amerindian ancestry; Ancestry informative markers; European ancestry; Single nucleotide polymorphism

Some studies of polymorphisms in prostate cancer (PCa) analyze individuals in a uniform manner, regardless of genetic ancestry. However, PCa aggressiveness differs between subjects of African descent and those of European extraction. Thus, genetic ancestry analysis may be used to detect population stratification in case-control association studies. We genotyped 11 ... more

J.S. Oliveira; R.S. Ferreira; L.M. Santos; L.J. Marin; R.X. Corrêa; M.R. Luizon; A.L. Simões; S.R. Gadelha; S.M.B. Sousa

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