Research Article

Related GMR Articles

Acute coronary syndromes; Cardiovascular disease; Coronary artery disease; Estrogen receptor 1; Meta-analysis; Myocardial infarction

The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scientific ... more

N. Jiang; G. Yang; C.L. Peng
HFE H63D polymorphism; Meta-analysis; Molecular epidemiology; Solid cancer

A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors. However, the clinical outcomes were inconsistent. Therefore, this meta-analysis was conducted to summarize the effect ... more

L.L. Shen; D.Y. Gu; T.T. Zhao; C.J. Tang; Y. Xu; J.F. Chen
Blood test; Leptin; Meta-analysis; Non-small cell lung carcinoma; Serum levels; Standardized mean differences

In this study, we analyzed the association between serum leptin levels and non-small cell lung carcinoma (NSCLC). By examining English and Chinese databases, we identified potential relevant studies for statistical analysis. Human-associated case-control studies evaluating the association between serum leptin levels and NSCLC according to the random-effect model were retrieved and ... more

J. Du; J.C. Han; Y.J. Zhang; G.B. Qi; Y. Zhang; H.B. Li
Cancer risk; Interleukin 6; Meta-analysis; rs1800796

The human IL6 [interleukin 6 (interferon, beta 2)] gene encodes IL-6, a cytokine which not only plays regulatory roles in inflammation, but may be also involved in the progression of cancer. Rs1800796 is a single nucleotide polymorphism (SNP) in the promoter region of IL6, and is associated with IL-6 production. A number of studies have been carried out to determine ... more

Y. Du; L. Gao; K. Zhang; J. Wang
ERCC2; Glioma; Meta-analysis; rs13181

Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the PubMed, Web of Science, Cochrane Library, and ... more

T.L. Jia; H.J. Wu; H.B. Wang; W.B. Ma; B. Xing
Adiponectin; Meta-analysis; Nonalcoholic fatty liver disease; Polymorphism

Numerous epidemiological investigations have evaluated the association between adiponectin gene T45G polymorphism and risk of nonalcoholic fatty liver disease (NAFLD). However, the results of these studies have proven to be inconsistent. Therefore, we conducted a meta-analysis to obtain a more accurate estimation of this association. Published articles were retrieved from PubMed and Web ... more

W. Zhang; L.Q. Zhu; X.L. Huo; J. Qin; G.Y. Yuan; W. Zhang; L.Q. Zhu; X.L. Huo; J. Qin; G.Y. Yuan; W. Zhang; L.Q. Zhu; X.L. Huo; J. Qin; G.Y. Yuan
Clinically negative node; Meta-analysis; Radical neck dissection; Radiotherapy; Supraglottic carcinoma

The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. The databases included the Chinese biomedical literature database, Medline, Cochrane ... more

Y.H. Liu; Z.W. Du
IFIH1; Meta-analysis; SLE; SLE clinical manifestations; SNPs

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C ... more

deAzevêdo Silva; S.C. Lima; C. Addobbati; R. Moura; L.A.Cavalcanti Brandão; J.A.Trés Pancoto; E.A. Donadi; S. Crovella; P. Sandrin-Garcia
Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo
ACE I/D polymorphism; Diabetic nephropathy; Genetic association; Meta-analysis; Systematic reviews

The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism could influence predisposition for diabetic nephropathy (DN) by vascular modulation in the kidney, through a direct effect on cellular hypertrophy. However, studies on the association between this polymorphism and DN report conflicting results. To help determine if this association ... more

L.C. Silveira; E.G. da Silva; R.M. Azevedo; L.R.Bdos Anjos; R.F. Chagas; E.C. Alcântara; R.S. Santos; A.A.S. Reis