Research Article

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04/30/2019
GSTM1; GSTT1; Polymorphism; Prognosis; Sickle cell anemia

Sickle cell anemia is one of the most common genetic diseases in Brazil. This disease has an autosomal recessive inheritance pattern with a point mutation on chromosome 11, which is the substitution of an adenine by thymine. This mutation leads to the exchange of a glutamic acid for a valine at residue 6 of the beta globin chain, resulting in an abnormal form of hemoglobin, the so-called ... more

O.S.Dias Neto; K.S.Fe Silva; A.M. Barbosa; D.A. Rodrigues; M.H. Lagares; I.R. da Costa; K.K.V.O. Moura
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GSTM1; GSTT1; Polymorphism; Prostate cancer; Risk factor

Prostate cancer (PCa) is the second most common type of tumor among men over 50 years old and its etiology includes environmental, demographic, and genetic risk factors. We investigated a possible association between GSTM1 and GSTT1 polymorphisms, sociodemographic, and clinical factors with PCa in a population of southwestern Bahia, Brazil. The ... more

L.C.F. de Souza; T.L.S. Brito; A.T. Almeida; Y.P. Muniz; P.B. Nishiyama; C.L. Souza; L. Tomazi
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Cervical cancer; GSTM1; GSTT1; Smoking

Human papillomavirus infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in ... more

A.L.M. Tacca; A.K. Lopes; C.A.S.T. Vilanova-Costa; A.M.T.C. Silva; S.H.N. Costa; N.A. Nogueira; J.E.P. Ramos; A.A. Ribeiro; V.A. Saddi
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Atherosclerosis; eNOS; GSTM1; GSTT1; Hypertension

Atherosclerosis is a multifactorial chronic inflammatory disease that occurs in response to endothelial aggression. Systemic arterial hypertension is the main risk factor for the formation of atheromas, increasing the risk of cardiovascular diseases. Several genes are involved in atherogenesis and hypertension. We analyzed polymorphisms of candidate genes that ... more

M.P. Moraes; K.S.Fe Silva; M.H. Lagares; A.M. Barbosa; J.V.M. Martins; F.L. Campedelli; I.R. da Costa; D.A. Rodrigues; K.K.V.O. Moura
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Alzheimer’s disease; Estrogen receptor; Meta-analysis; Polymorphism

The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms. A ... more

Y.H. Lee; G.G. Song
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Esophageal cancer; Meta-analysis; p53 codon 72; Polymorphism

Although many epidemiologic studies have investigated the p53 codon 72 polymorphism and its association with esophageal cancer (EC) in China, definite conclusions could not be drawn. To clarify the effects of p53 codon 72 polymorphism on the risk of EC, we performed a meta-analysis on the Chinese population. A total of 13 studies including 3308 patients and 5115 controls were involved in ... more

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Meta-analysis; Polymorphism; Pulmonary tuberculosis; Tumor necrosis factor

The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls ... more

Y.H. Lee; G.G. Song
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Gastric cancer; Meta-analysis; MicroRNA; Polymorphism

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

Y.P. Gu; Q.Y. Yuan; H. Zhang; C.J. Wang; F. Zhou
12/29/2015
Meta-analysis; Polymorphism; Prostate cancer

Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independently by two investigators. Pooled ... more

H.S. Zhu; J.F. Zhang; J.D. Zhou; M.J. Zhang; H.X. Hu
12/29/2015
Interleukin-10; Meta-analysis; Nasopharyngeal carcinoma; Polymorphism; Promoter genes

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort ... more

Y.F. Yu; Z.G. Han; W.B. Guo; G.J. Zhang; J.K. Yang; F.L. Wu; Q.Y. Ou; Y.H. Li; X.Y. Cai; Z.N. Zhan; J.H. Chen; W.L. Xie; L. Tang; C.D. Liu

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