Research Article

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12/29/2015
A1166C; Angiotensin II type 1 receptor; Gene polymorphism; IgA nephropathy; Meta-analysis

Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a meta-analysis. Articles were identified in the ... more

J.M. Xu; X. Song; F. Gao; R. Wang
12/14/2015
Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

W. Pan; H. Liao
12/11/2015
Bone tumor; CYP1A1; Genetic susceptibility; Genotype; GSTM1

Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene ... more

L. Li; J.G. Li; C.Y. Liu; Y.J. Ding
05/25/2016
CYP1A1; Estrogen receptor β; GSTM1; GSTT1; p53; Progesterone receptor

In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response ... more

K.S.F. Silva; K.K.V.O. Moura; K.S.F. Silva; K.K.V.O. Moura
05/23/2016
CYP1A1; Meta-analysis; Oral cancer; Polymorphism

Numerous studies regarding the association between the CYP1A1 MspI polymorphism and oral cancer risk in Asian populations have shown controversial results. To get a more precise estimation of this relationship, we conducted a comprehensive meta-analysis. PubMed, the Cochrane Library, Elsevier Science Direct, Web of Knowledge, the Chinese National Knowledge Infrastructure, VIP, ... more

J.L. Xu; R. Xia; L. Sun; X. Min; Z.H. Sun; C. Liu; H. Zhang; Y.M. Zhu; J.L. Xu; R. Xia; L. Sun; X. Min; Z.H. Sun; C. Liu; H. Zhang; Y.M. Zhu
09/21/2015
Cervical cancer; Cone-beam computed tomography; Image-guided radiation therapy; Setup error

This study aimed to evaluate cone-beam computed tomography setup errors during cervical cancer treatment and the effects of these errors on acute radiation toxicity and treatment efficacy. A total of 170 cervical cancer patients were randomly divided into image-guided radiation therapy (IGRT; 86 patients) and intensity-modulated radiation therapy (IMRT; 84 patients) groups to receive IGRT ... more

S. Xin
08/14/2015
Bacterial vaginosis; Cervical cancer; Cervical intraepithelial neoplasia; Human papillomavirus

We investigated the association between bacterial vaginosis (BV) and human papillomavirus (HPV) infection in Papanicolaou smears in a Brazilian population. Cross-sectional analysis was performed on 673 samples collected from women attending public health centers in Olinda (PE, Brazil) by conventional cytology methodology and molecular analysis, PCR tests (GP5+/6+ and MY09/11). Cytological ... more

A.L. Peres; J.R.S.L. Camarotti; M. Cartaxo; N. Alencar; R.C. Stocco; W. Beçak; N.T. Pontes-Filho; R.F.F. Araújo; J.L. Lima-Filho; D.B.G. Martins
07/06/2015
Apoptosis; C-33A; Caspase; Cervical cancer; FoxO1; TNF-α

Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer. In our study, we used the well- ... more

B. Zhang; L. Gui; L. Zhu; X. Zhao; Y. Yang; Q. Li
12/22/2015
Biomarker; Cervical cancer; Cervical intraepithelial neoplasia; miR-196a; Prognosis

Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy volunteers were recruited. Quantitative ... more

P. Liu; F. Xin; C.F. Ma
12/17/2015
Cervical cancer; HLA-DQB1; PCR-SBT; Predisposing genes

In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were ... more

L. Han; S. Husaiyin; L. Wang; K.D. Wusainahong; X. Fu; M. Niyazi

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