Research Article

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10/30/2015
Gekko japonicus; Genetic diversity; Microsatellite; Polymorphism

Twelve polymorphic microsatellite loci were isolated in the Japanese gecko, Gekko japonicus. We genotyped one population from Wenzhou, Zhejiang Province, China (N = 36). The mean number of observed alleles per locus was 7.3 (range 4 to 13). Observed and expected heterozygosity values ranged from 0.200 to 0.944 and from 0.395 to 0.797, respectively. One locus (GJ20) showed ... more

L. Wei; W.W. Shao; H.B. Zhou; J. Ping; L.M. Li; Y.P. Zhang
10/30/2015
Cancer; Meta-analysis; Polymorphism; Vascular endothelial growth factor

The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched ... more

J.Y. Ban; J.I. Shin; C.H. Oh
10/28/2015
APOA-I; APOE; Coronary heart disease; HDL-C; High-density lipoprotein cholesterol; Polymorphism

Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to ... more

Y. Huang; H.D. Ye; X. Gao; S. Nie; Q.X. Hong; H.H. Ji; J. Sun; S.J. Zhou; B. Fei; K.Q. Li; J.K. Zhao; Z.P. Wang; M.Q. Xu; S.W. Duan
10/27/2015
Chinese population; Gastric cancer; IL-17; Polymorphism

We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A and rs3748067C ... more

W.T. Qi; J.L. Gao; S.S. Zhang
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Polymorphism; Retinal vein occlusion; RVO; Thrombophilia

In this study, we assessed the prevalence of polymorphisms in genes involved in hyperhomocysteinemia or hemostasis to shed light on their role, if any, in retinal vein occlusion (RVO). We recruited 37 Italian patients (17 men and 20 women) with a diagnosis of central or branch RVO based on fundus examination and retinal fluorescein angiography, as well as 45 healthy controls. Risk ... more

L. De Polo; P.E. Maltese; E. Rigoni; M. Bertelli; S. Cecchin; G. Staurenghi; G. Stoppa
10/27/2015
Chronic obstructive pulmonary disease; Polymorphism; Proteinase-activated receptor-1

We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism assay was used to assess ... more

C.M. Yun; X.Y. Sang
10/21/2015
A-20C; Angiotensinogen gene; Essential hypertension; Meta-analysis; Polymorphism

The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved from PubMed. ... more

R. Zeng; Q.P. Wang; M.X. Fang; J. Zhuang; R.X. Fan
10/19/2015
Censured data; Mixed model; Polymorphism

The aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorphism (SNP) plus the halothane gene]. The data were corrected ... more

V.S. Santos; M. Filho; M.D.V. Resende; C.F. Azevedo; P.S. Lopes; S.E.F. Guimarães; L.S. Glória; F.F. Silva
10/16/2015
Coronary artery disease; Interleukin gene; Polymorphism

We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). A total of 410 individuals with CAD were ... more

H.T. Yang; S.L. Wang; L.J. Yan; P. Qian; H.Y. Duan

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