Research Article

Related GMR Articles

Glioma; Single-nucleotide polymorphism; susceptibility; X-ray cross-complementing group 3

The susceptibility to glioma is not well understood. It has been suggested that the X-ray cross complementing group 3 (XRCC3) gene influences the capacity to repair DNA damage, leading to increased glioma susceptibility. In this study, we evaluated the relationship between XRCC3 mutations and glioma risk. Genotypes were assessed in 389 Chinese glioma patients and 358 healthy controls. ... more

J.Y. Huang; J.F. Yang; Q. Qu; J. Qu; F. Liu; F.E. Liu; T. Xiong; S.H. Lu
Autoimmune disease; Human leukocyte antigen-G; Indel polymorphism; Meta-analysis; susceptibility

Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and ... more

S.K. Kim; K.H. Jeong; I.J. Kang; J.H. Chung; M.K. Shin; M.H. Lee
COPD; FPRP; Polymorphism; susceptibility

Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value. We extracted the odds ratio (OR) and 95% confidence interval ... more

Z.P. Yan; X. Tong; S.T. Liu; Y. Ma; S.F. Peng; X. Yang; H. Fan; Z.P. Yan; X. Tong; S.T. Liu; Y. Ma; S.F. Peng; X. Yang; H. Fan
Amaranthus; Neuronal cells; Oxidative stress; RAGE

Amaranthus plants, or spinach, are used as food sources worldwide. Amaranthus leaves are rich in antioxidant compounds, which act as free radical scavengers. Oxidative stress caused by the aberrant production of reactive oxygen species (ROS) represents an important mechanism for neuronal dysfunction and cell loss in different neurodegenerative disorders. The ... more

W. Amornrit; R. Santiyanont; W. Amornrit; R. Santiyanont; W. Amornrit; R. Santiyanont
Coronary artery disease; IL-17A; IL-17F; Polymorphism

A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People’s Hospital between May 2012 and May 2014. The IL-17A ... more

G.Y. Geng; H.L. Liu; Y.J. Zhao; L. Wu; L. Mao; N. Ba
DNA repair genes; Osteosarcoma; Overall survival; Polymorphism

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed ... more

M.J. Wang; Y. Zhu; X.J. Guo; Z.Z. Tian
Chemotherapy; Clinical outcome; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, ... more

J. Wang; T. Wang; G.Y. Yin; L. Yang; Z.G. Wang; X.B. Bu
Cancer risk; Polymorphism; Renal cell carcinoma; Vascular endothelial growth factor

We conducted this case-control study to assess the role of the VEGF -2578C/A, +1612G/A, +936C/T and -634G/C gene polymorphisms in the development of renal cell carcinoma (RCC). A hospital-based case-control study was conducted in a 360 consecutive primary RCC patients and 360 age and gender-matched controls during January 2010 and January 2014. The polymerase chain reaction-restriction ... more

B.L. Shen; Q.S. Qu; S.Z. Miao; Y.X. Zhang
broiler; Candidate gene; Polymorphism; Production trait; QTL

Genetic selection for production traits has resulted in a rapid improvement in animal performance and development. Previous studies have mapped quantitative trait loci for body weight at 35 and 41 days, and drum and thigh yield, onto chicken chromosome 4. We investigated this region for single nucleotide polymorphisms and their associations with important economic traits. Three positional ... more

F. Pértille; R. Zanella; A.M. Felício; M.C. Ledur; J.O. Peixoto; L.L. Coutinho
Advanced non-small cell lung cancer; Clinical outcome; GSTP1; Polymorphism; XRCC1

We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length ... more

J.Y. Liu; L.R. Li; Q.M. Liu