Research Article

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hsa-miR-146a; Intracranial aneurysm; Polymorphism; susceptibility

Vascular inflammation has been shown to be involved in the pathogenesis of intracranial aneurysms (IA). MiRNAs are key molecules that participate in the regulation of many important biological processes including inflammation. Studies on the hsa-miR-146a rs2910164 polymorphism and its association with different inflammatory related diseases have engendered inconsistent ... more

X.T. Sima; J.G. Xu; J. Li; C. You
12/17/2015
Meta-analysis; NAT2; Pancreatic cancer; Polymorphism; susceptibility

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to assess this relationship ... more

J.X. Liang; W. Gao; Y. Liang; X.M. Zhou
11/22/2011
b-actin; DEP chip; Electrochemical biosensor; Gene expression; Hoechst 33258; RAGE

An electrochemical biosensor, using a disposable electrochemical printed chip aggregation by the bisbenzimide dye (Hoechst 33258), was used for detecting the expression of β-actin and RAGE genes. Using linear sweep voltammetry, the expression of these two genes in HeLa and HepG2 cell lines was determined based on anodic peak current, and the results were compared with conventional agarose ... more

P. Kittimongkolsuk; T. Tencomnao; R. Santiyanont
06/15/2010
AGER; Genetic polymorphisms; Gestational diabetes; RAGE; Single nucleotide polymorphisms

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, ... more

I.C.R. Santos; D.R. Daga; H.R. Frigeri; R.R. Réa; A.C.R. Almeida; E.M. Souza; F.O. Pedrosa; C.M.T. Fadel-Picheth; G. Picheth
03/01/2012
Gene polymorphism; RAGE; Retinopathy

Diabetic retinopathy is the most common diabetic eye disease, occurring in about 60% of type 2 diabetic patients. Other than known clinical risk factors, the influence of genes has been suggested as part of the development of diabetic retinopathy. We investigated the association of Gly82Ser, 1704G/T and 2184A/G polymorphisms in the RAGE gene with retinopathy in type 2 diabetic patients in ... more

Z.X. Ng; U.R. Kuppusamy; R. Poh; I. Tajunisah; A.C.A. Koay; K.C.S. Fong; K.H. Chua
08/28/2015
CD4+CD45+ regulatory T cells; Flow cytometry; Immune regulation; Ulcerative colitis

The objectives of this study were to explore the expression of peripheral blood CD4+CD45+ T cells in patients with ulcerative colitis (UC) and determine its clinical value. We selected 80 patients with UC from the First Affiliated Hospital of Liaoning Medical University from March 2012 to December 2013. Of these, 27 had mildly active, 28 moderately active, and 25 severely active UC. We also ... more

L.Y. Guo; Y.R. Li; X.P. Jin
12/22/2015
Association study; CASP genes; Periodontal disease; Polymorphism

Caspases (CASP) are intracellular proteases that play roles as mediators of apoptosis. Activation of caspase 3 is enhanced in chronic periodontitis. Thus, we hypothesized that single nucleotide polymorphisms (SNPs) of CASP genes might be associated with this condition in the Korean population. To investigate whether such polymorphisms might be involved in the development of ... more

S.W. Kang; S.K. Kim; J.H. Chung; J.Y. Ban
08/14/2015
Association study; Schizophrenia; SNP; VRK2 gene

Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 ... more

B. Zhang; C.Y. Gao; H.B. Zhang; B. Yang; J.F. Yin; S.G. Wei; Y.S. Zhu; X.N. Jia; S.B. Li
12/01/2015
Association study; Candidate genes; Insulin resistance; Quantitative traits; Type 2 diabetes mellitus

Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single nucleotide polymorphisms (SNPs) and metabolic syndrome-related ... more

F.J. Wei; C.Y. Cai; P. Yu; J. Lv; C. Ling; W.T. Shi; H.X. Jiao; B.C. Chang; F.H. Yang; Y. Tian; M.S. Li; Y.H. Wang; L. Zou; J.M. Shi; L.M. Chen; W.D. Li
09/16/2016
Association study; CD4; Holstein; Milk fat; Production traits; Single nucleotide polymorphism

Cluster of differentiation 4 gene (CD4) is well known for its role in immunity, but its effects on production traits remain to be elucidated. The present study was designed to explore single nucleotide polymorphisms (SNPs) in the exons, flanking introns, and promoter of CD4, as well as to analyze their effects on milk production traits (percentage of protein, fat, and ... more

T. Usman; Y. Yu; L. Zhai; C. Liu; X. Wang; Y. Wang; T. Usman; Y. Yu; L. Zhai; C. Liu; X. Wang; Y. Wang

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