Research Article

Related GMR Articles

07/03/2015
Benign prostate hyperplasia; Genetic polymorphism; Prostate cancer

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of ... more

E. Ersekerci; M. Sofikerim; S. Taheri; A. Demirtas; F. Halis
07/03/2015
HNF1B rs4430796 (A>G) polymorphism; Meta-analysis; Prostate cancer

Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through May 18, 2014, were ... more

Y. Zhao; J. Liang; J.G. Qi; N. Yang; G. Wu; Y.L. Lin; J.Y. Cao; Q. Wang; Q.C. Wang
07/31/2019
GSTM1; GSTT1; Polymorphism; Prostate cancer; Risk factor

Prostate cancer (PCa) is the second most common type of tumor among men over 50 years old and its etiology includes environmental, demographic, and genetic risk factors. We investigated a possible association between GSTM1 and GSTT1 polymorphisms, sociodemographic, and clinical factors with PCa in a population of southwestern Bahia, Brazil. The ... more

L.C.F. de Souza; T.L.S. Brito; A.T. Almeida; Y.P. Muniz; P.B. Nishiyama; C.L. Souza; L. Tomazi
08/10/2015
Alzheimer’s disease; Estrogen receptor; Meta-analysis; Polymorphism

The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms. A ... more

Y.H. Lee; G.G. Song
08/07/2015
Esophageal cancer; Meta-analysis; p53 codon 72; Polymorphism

Although many epidemiologic studies have investigated the p53 codon 72 polymorphism and its association with esophageal cancer (EC) in China, definite conclusions could not be drawn. To clarify the effects of p53 codon 72 polymorphism on the risk of EC, we performed a meta-analysis on the Chinese population. A total of 13 studies including 3308 patients and 5115 controls were involved in ... more

J.Z. Peng; L. Xue; D.G. Liu; Y.H. Lin
07/31/2015
Meta-analysis; Polymorphism; Pulmonary tuberculosis; Tumor necrosis factor

The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls ... more

Y.H. Lee; G.G. Song
07/28/2015
Gastric cancer; Meta-analysis; MicroRNA; Polymorphism

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

Y.P. Gu; Q.Y. Yuan; H. Zhang; C.J. Wang; F. Zhou
12/29/2015
Interleukin-10; Meta-analysis; Nasopharyngeal carcinoma; Polymorphism; Promoter genes

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort ... more

Y.F. Yu; Z.G. Han; W.B. Guo; G.J. Zhang; J.K. Yang; F.L. Wu; Q.Y. Ou; Y.H. Li; X.Y. Cai; Z.N. Zhan; J.H. Chen; W.L. Xie; L. Tang; C.D. Liu
12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
12/29/2015
Cardiovascular disease; Coronary artery disease; Gene; Meta-analysis; Polymorphism; PPARγ2

This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of ... more

Y. Li; J. Zhu; J.Q. Ding

Pages