Research Article

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03/30/2017
Animals; Apoptosis; Blood glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ginsenosides; Glucose; Insulin; JNK Mitogen-Activated Protein Kinases; Lipids; Liver; Liver Diseases; male; Random Allocation; Rats; Rats, Sprague-Dawley

Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, especially in those with high levels of blood lipid. In this study, ... more

W. Tian; L. Chen; L. Zhang; B. Wang; X.B. Li; K.R. Fan; C.H. Ai; X. Xia; S.D. Li; Y. Li
2017 Apr 13
Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Breast neoplasms; Carotenoids; Cell proliferation; Humans; Lycopene; MCF-7 cells; Tumor Suppressor Protein p53

Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we aimed to illustrate the effect of lycopene on tumor cell ... more

S.J. Peng; J. Li; Y. Zhou; M. Tuo; X.X. Qin; Q. Yu; H. Cheng; Y.M. Li
2017 May 10
Antibiotics, Antineoplastic; Apoptosis; Bleomycin; Cell line; Endoplasmic reticulum stress; Heat-shock proteins; Human Umbilical Vein Endothelial Cells; Humans; Receptors, G-Protein-Coupled; Transcription Factor CHOP

In this study, we investigated the effects of pingyangmycin (PYM) on the growth inhibition and apoptosis of human umbilical vein endothelial cells (HUVEC). In this study, we aimed to explore the optimal concentration of PYM to induce the apoptosis of HUVEC and to determine its mechanism of action. After treatment of HUVEC with different concentrations of PYM for 24 h, cell counting kit-8 (CCK- ... more

Y.D. Huang; X. Tong; Q. Chen; S.W. Xia; Y. Zhuo; Z.H. Kang; X.Y. Xue
2017 Jun 29
Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Colorectal neoplasms; Curcumin; Drug Resistance, Neoplasm; HSP27 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Proto-Oncogene Proteins c-bcl-2; Survivin

Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combination with curcumin on HCT-8/5 ... more

Y.X. Fan; P. Abulimiti; H.L. Zhang; Y.K. Zhou; L. Zhu
10/05/2017
Apoptosis; ERK signal pathway; Hepatic stellate cells; JNK signal pathway
This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related kinase (ERK) signaling pathways. Human ... more
L. Wu; Y. Liu; L. Shi; B. Zhang; A.Carolina P. Pasian; A. Moroz
11/30/2019
Apoptosis; Gene; Glioblastoma; miRNA

Glioblastoma is considered incurable, even with a combination of therapies (chemo and radiotherapy), and surgical resection. New therapeutic approaches are needed to improve the prognosis of patients with glioblastoma. In recent decades, research has focused on molecular biology of brain tumors. We examined the role of programmed cell death, apoptosis, through two ... more

F. Pansani; L.P. Turra; F.S.Lizarte Neto; M.Lde A. Cirino; L.F. Tirapelli; F.M. Peria; C.G.Carlotti Junior; D.Pda C. Tirapelli

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