Research Article

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12/29/2015
Cervical cancer; COMT; CYP1A1; Gene polymorphism

The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were analyzed: a) 81 ... more

J.P. Kleine; C.M. Camargo-Kosugi; C.V. Carvalho; F.C. Silva; I.D.C.G. Silva
12/22/2015
Biomarker; Cervical cancer; Cervical intraepithelial neoplasia; miR-196a; Prognosis

Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy volunteers were recruited. Quantitative ... more

P. Liu; F. Xin; C.F. Ma
12/17/2015
Cervical cancer; HLA-DQB1; PCR-SBT; Predisposing genes

In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were ... more

L. Han; S. Husaiyin; L. Wang; K.D. Wusainahong; X. Fu; M. Niyazi
12/16/2015
Bcl-2; Cervical cancer; KAI1; Metastasis; Survivin

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation with metastasis in cervical ... more

X.L. Zhou; M. Wang
12/14/2015
Autophagy; Cervical cancer; Chemosensitivity; Cisplatin

Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy in cisplatin-sensitivity of CC cells via ... more

W.M. Lin; Z.G. Li
10/09/2015
Cervical cancer; IL-17A; IL-17F; Interleukin-17A; Interleukin-17F; Single nucleotide polymorphism

We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs2275913, rs3748067, and rs3819025) and IL-17F (rs763780, ... more

L. Li; Y.L. Tian; X.M. Lv; H.F. Yu; Y.Y. Xie; J.D. Wang; W. Shi
10/02/2015
Cervical cancer; Ebp1; Immunohistochemistry; p53

In this study, the ErbB3-binding protein (Ebp1) and p53 protein expression in cervical cancer tissues, and its significance in the prognosis of the disease was investigated. Ebp1 and p53 protein expression was detected by immunohistochemical analysis in cervical cancer tissues (N = 60) and normal tissues adjacent to the cancer tissues (N = 60). The rates of positive Ebp1 and p53 protein ... more

L. Liu; X.D. Li; H.Y. Chen; J.S. Cui; D.Y. Xu
03/22/2016
Case-control study; Cervical cancer; Incidence; Programmed death 1; Single nucleotide polymorphism

The association of the programmed cell death-1 PD1.5 C>T polymorphism with cervical cancer risk has not been investigated. In this hospital-based case-control study, we analyzed 256 patients with cervical cancer and 250 healthy controls. Pearson chi-square test was used to examine differences in the distribution of genotypes between cases and controls. Association between the ... more

X.F. Li; X.Q. Jiang; J.W. Zhang; Y.J. Jia; X.F. Li; X.Q. Jiang; J.W. Zhang; Y.J. Jia; X.F. Li; X.Q. Jiang; J.W. Zhang; Y.J. Jia
11/03/2016
Age distribution; Cervical cancer; Human papilloma virus; Multiple infection; Subtype distribution

The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV infection ... more

J. Li; Y.Y. Wang; X.F. Tian; X. Nan; T. Yan; P. Wang; Y.L. Fu; G.Q. Wang
02/25/2019
Cervical cancer; GSTM1; GSTT1; Smoking

Human papillomavirus infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in ... more

A.L.M. Tacca; A.K. Lopes; C.A.S.T. Vilanova-Costa; A.M.T.C. Silva; S.H.N. Costa; N.A. Nogueira; J.E.P. Ramos; A.A. Ribeiro; V.A. Saddi

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