Research Article

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08/14/2015
Bacterial vaginosis; Cervical cancer; Cervical intraepithelial neoplasia; Human papillomavirus

We investigated the association between bacterial vaginosis (BV) and human papillomavirus (HPV) infection in Papanicolaou smears in a Brazilian population. Cross-sectional analysis was performed on 673 samples collected from women attending public health centers in Olinda (PE, Brazil) by conventional cytology methodology and molecular analysis, PCR tests (GP5+/6+ and MY09/11). Cytological ... more

A.L. Peres; J.R.S.L. Camarotti; M. Cartaxo; N. Alencar; R.C. Stocco; W. Beçak; N.T. Pontes-Filho; R.F.F. Araújo; J.L. Lima-Filho; D.B.G. Martins
12/28/2015
Autoimmune disease; CTLA-4; PTPN22; TNF-α; Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polyglandular syndrome type III (APSIII); ... more

N.A.C. Tavares; M.M.S. Santos; R. Moura; J. Araújo; R.L. Guimarães; S. Crovella; L.A.C. Brandão
12/17/2015
IL-6; miR-31; NF-κB; Peripheral blood mononuclear cells; TNF-α; Tuberculosis

We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People’s Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in ... more

J.X. Wang; J. Xu; Y.F. Han; Y.B. Zhu; W.J. Zhang
12/09/2015
Celiac disease; HLA-DQ; IL-6; TNF-α

The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibility to CD. A case-control of 192 patients ... more

R.Mde Albuque Maranhão; F.A.Martins Esteves; S. Crovella; L. Segat; P.R.Eleutério Souza
12/07/2015
Meta-analysis; Polymorphism; TNF-α; Urogenital cancer

We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the ... more

J. Cai; M.Y. Yang; N. Hou; X. Li
10/02/2015
Glioma invasiveness; Heat shock factor-1; HSF1; Thermotherapy; TNF-α; Tumor necrosis factor-α

Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry were used to investigate the levels of TNF-α mRNA and heat shock ... more

L.J. Qin; T. Zhang; Y.S. Jia; Y.B. Zhang; Y.X. Zhang; H.T. Wang
10/05/2015
BRL-3A cells; Connexin 32; Gap junction; Oleamide; siRNA; TNF-α

The aim of this study was to observe the influence of gap junction (GJ) functional changes on the hepatotoxicity of TNF-α. Three different methods were employed to study functional effects of the GJ inhibition: 1) pretreatment with a GJ inhibitor; 2) inoculation of cells at high and low densities; and 3) inhibition of the expression of connexin 32 (Cx32) by small inhibitory RNA ... more

Z.Y. Chen; R. Wang; F. Huang; D.D. Yuan; S.R. Li
03/22/2016
IL-6; Immunohistochemistry; Invasive pituitary adenomas; TNF-α

The aim of this study was to investigate expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in invasive pituitary adenomas (IPAs). The streptavidin peroxidase immunohistochemical method was employed to detect their expression in 40 cases of IPA and 40 of non-invasive pituitary adenoma (NIPA). TNF-α and IL-6 were found to be upregulated in IPA tissue compared with that ... more

J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan; J.L. Wu; J.Y. Qiao; Q.H. Duan
03/30/2020
Endostatin; MDAMB 231; TNF-α; TRAIL; Vinorelbine

Surgery, chemotherapy and radiotherapy, which are known as conventional cancer treatments, have been applied for more than 40 years. Because the target of chemotherapy is tumor cells, treatment agents are used at high doses during application and this creates toxic responses, causing side effects in normal cells. Furthermore, due to the high doses, cancer cells ... more

C. Kilit; E.A. Aydemir; K. Fiskin
09/21/2015
Cervical cancer; Cone-beam computed tomography; Image-guided radiation therapy; Setup error

This study aimed to evaluate cone-beam computed tomography setup errors during cervical cancer treatment and the effects of these errors on acute radiation toxicity and treatment efficacy. A total of 170 cervical cancer patients were randomly divided into image-guided radiation therapy (IGRT; 86 patients) and intensity-modulated radiation therapy (IMRT; 84 patients) groups to receive IGRT ... more

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