Research Article

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11/13/2015
Insulin-like growth factors; Osteoporosis; Polymorphism; Postmenopausal female

The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. ... more

Y.K. Wei; H.L. Ma; Y.Z. Guo; B.H. Yang; W.X. Pang
07/13/2015
Polymorphism; Renal cell carcinomas; Vascular endothelial growth factor

We conducted a case-control study in a Chinese population to assess whether 5 common single-nucleotide polymor­phisms in the vascular endothelial growth factor gene (VEGF) affect the risk of renal cell carcinoma (RCC). The study population in­cluded 266 RCC patients who were newly diagnosed and histologi­cally confirmed to have RCC as well as 532 cancer-free controls. Genotyping ... more

W. Xian; H. Zheng; W.J. Wu
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Expression pattern; Insulin-like growth factors; Muscle tissue

Insulin-like growth factors (IGFs) are regulators that modulate the proliferation and differentiation of muscle tissues. We quantified the messenger RNA (mRNA) expression of IGF-I, IGF-II, and type I and II IGF receptors (IGF-IR and IGF-IIR) in muscle tissues including the breast, leg, and myocardium during an early postnatal development growth stage (post-hatching weeks 1-8) in ducks. ... more

C.L. Song; H.H. Liu; J. Kou; L. Lv; L. Li; W.X. Wang; J.W. Wang
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-634C/G; IL-6 polymorphism; Meta-analysis; Osteoporosis

Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched for eligible studies published up ... more

L. Yan; R. Hu; S. Tu; W.J. Cheng; Q. Zheng; J.W. Wang; W.S. Kan; Y.J. Ren
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COL1A1; Gene polymorphism; Meta-analysis; Osteoporosis

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
07/27/2015
BMP-2; BMP-4; Osteoporosis; Red yeast rice

Osteoporosis is the most common bone disease, affecting millions of people worldwide and leading to significant morbidity and high costs. Monacolin K, an extract of red yeast rice (RYR, Hongqu), plays important roles in the management of dyslipidemia, coronary heart disease, and diabetes. Our study aimed to investigate the protective effect of monacolin K on ovariectomy-induced ... more

Y.F. Wang; W.T. Liu; C.Y. Chen; H.P. Ke; H.L. Jiang; X.L. Chen; S.Y. Shi; W. Wei; X.N. Zhang
12/02/2015
Catechol-O-methyl transferase; Cytochrome P450 17; Estrogen receptor 1; Osteoporosis; Polymorphism

In this study, we evaluated genetic factors related to the mineral density during post-menopause. We evaluated 110 women in the first 5 years post-menopause, without previous hormone replacement therapy. Cytochrome P450 17 (CYP17) (rs743572), catechol-O-methyl transferase (COMT) (rs4680), and estrogen receptor 1 (ESR1) (rs9322331) were examined for the ... more

C.G. Gonçalves; B.C. Almeida; C.M. Camargo-Kosugi; A.M.M. Costa; I.D.C.G. Silva; M.A. Haidar
3/16/2017
Alendronate; Animals; Bone Density Conservation Agents; Bone morphogenetic protein 2; Cytokines; Disease Models, Animal; Dyskinesias; Female; Fibroblast Growth Factor 2; Humans; Insulin-like growth factor I; Osteoporosis; Ovariectomy; Rabbits; Treatment outcome; Up-Regulation

Alendronate regulates the activity of osteoclasts and healing of osteoporosis. This study investigated the effect of alendronate on bone healing and changes in the levels of cytokines. Bilateral ovaries of 10 adult female rabbits were removed surgically in aseptic condition to establish the animal model of osteoporosis. Five rabbits in group A were treated with alendronate (1.15 mg·kg·week) ... more

C.T. Liu; X.J. Yuan; G.C. Gao
03/29/2021
Calcium and vitamin D; Cross- sectional; Exercise; Fosamax drug; Lifestyle; Menopause; Osteoporosis; Prevalence; T-score

Osteoporosis is a common pathology and a cause of disability and reduced quality of life invarious developing countries.  An urgent issue in this context is the study of risk factors for osteoporosis, especially those that can be modified. We conducted a cross-sectional study in Vietnam.  The study was conducted in the city of Vinh and involved 2065 respondents who ... more

S.C. Thuc; T.H.L. Thi; M.T.N. Thi; H.D. Vinh
03/30/2021
Bone Density; Fractures; Osteoporosis; Postmenopausal osteopenia; Zoledronic acid

We assessed the effectiveness of Aclasta for osteoporosis in patients with femoral head fractures at Thong Nhat Hospital in Ho Chi Minh City. A total of 156 patients with femoral head fractures and osteoporosis in the orthopedic department at Thong Nhat in Ho Chi Minh City were assigned to a randomized controlled trial from 01 Jan 2013 to 01 Jan 2014, divided into ... more

V.T. Toan; B.V. Anh

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