Research Article

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10/27/2015
Abiotic stress; bZIP; Carrot; Evolution; Group A; Transcription factor

The basic-region/leucine-zipper (bZIP) family is one of the major transcription factor (TF) families associated with responses to abiotic stresses. Many members of group A in this family have been extensively examined and are reported to perform significant functions in ABA signaling as well as in responses to abiotic stresses. In this study, 10 bZIP factors in carrot were classified ... more

F. Que; G.L. Wang; Y. Huang; Z.S. Xu; F. Wang; A.S. Xiong
03/04/2016
Correlation analysis; Desmoglein 4; Diversity; Evolution; Goat

Desmoglein 4 (DSG4) has an important role in the development of wool traits in domestic animals. The full-length DSG4 gene, which contains 3918 bp, a complete open-reading-frame, and encodes a 1040-amino acid protein, was amplified from Liaoning cashmere goat. The sequence was compared with that of DSG4 from other animals and the results show that the DSG4 ... more

G.X. E; Y.J. Zhao; Y.H. Ma; G.L. Cao; J.N. He; R.S. Na; Z.Q. Zhao; C.D. Jiang; J.H. Zhang; S. Arlvd; L.P. Chen; X.Y. Qiu; W. Hu; Y.F. Huang; G.X. E; Y.J. Zhao; Y.H. Ma; G.L. Cao; J.N. He; R.S. Na; Z.Q. Zhao; C.D. Jiang; J.H. Zhang; S. Arlvd; L.P. Chen; X.Y. Qiu; W. Hu; Y.F. Huang
09/25/2015
ASB15 gene; Chicken; Growth and carcass traits; Single nucleotide polymorphism

ASB15 is a member of the ankyrin repeat and suppressor of cytokine signaling box family, and is predominantly expressed in skeletal muscle. In the present study, an F2 resource population of Gushi chickens crossed with Anka broilers was used to investigate the genetic effects of the chicken ASB15 gene. Two single nucleotide polymorphisms (SNPs) (rs315759231 A>G and ... more

Y.C. Wang; R.R. Jiang; X.T. Kang; Z.J. Li; R.L. Han; J. Geng; J.X. Fu; J.F. Wang; J.P. Wu
09/22/2015
Chemotherapy; ERCC1; ERCC2; Osteosarcoma; Overall survival; Single nucleotide polymorphism

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess ... more

Q. Zhang; L.Y. Lv; B.J. Li; J. Zhang; F. Wei
09/22/2015
Cardiac troponin T type-2 gene; Dilated cardiomyopathy; Gene mutation; Nuclear lamina protein gene; Single nucleotide polymorphism; Tropomyosin gene

Dilated cardiomyopathy (DCM) is a myocardial disease with a high mortality rate. Approximately 40 genes have been found to be associated with DCM to date. Non-familial DCM can also be caused by gene mutations, suggesting that genetic factors were involved in the pathogenesis of DCM; therefore genetic testing is beneficial for the early diagnosis of DCM, which can facilitate the ... more

Y.D. Li; Y.T. Ji; X.H. Zhou; H.L. Li; H.T. Zhang; Y. Zhang; J.X. Li; Q. Xing; J.H. Zhang; Y.F. Hong; B.P. Tang
09/21/2015
3'-UTR; Coronary artery disease; Gene; MEF2A; Single nucleotide polymorphism

Association of variants in the myocyte enhancer factor 2A (MEF2A) gene and the risk of coronary artery disease (CAD) has drawn much attention but remains controversial. We hypothesized that the 3'-untranslated region (3'-UTR) of this gene could harbor functionally relevant nucleotide changes. Here, we assessed the association between single nucleotide polymorphisms (SNPs) in the ... more

X.C. Huang; W. Wang
09/09/2015
Benign prostatic hyperplasia; Interleukin-28B; Interleukin-28B receptor α; Lower urinary tract symptoms; Single nucleotide polymorphism

The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917, and IL-28Rα rs10903035 and ... more

L. .Xiao; L.B. Gao; Q. Wei
08/28/2015
Han people; Ischemic stroke; Mongol; Phosphodiesterase 4D gene; Single nucleotide polymorphism

We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Han patients) were detected ... more

J.P. Shi; W.D. Chen; J.Q. Zhou; M.M. Xue; F. Xue; H.Z. Li; Z.P. Xu
08/19/2015
Gout; Metabolic indices; Single nucleotide polymorphism; SLC2A9; ZNF518B

Current evidence suggests that heredity and metabolic syndrome contribute to gout progression. SLC2A9 and ZNF518B may play a role in gout progression in different populations, but no studies have focused on the Tibetan Chinese population. In this study, we determined whether variations in these 2 genes were correlated with gout-related indices in Chinese-Tibetan gout ... more

X.Y. Zhang; T.T. Geng; L.J. Liu; D.Y. Yuan; T. Feng; L.L. Kang; T.B. Jin; C. Chen
08/07/2015
Body measurement trait; CIDEC; Meat quality trait; Qinchuan cattle; Single nucleotide polymorphism

Previous studies have shown that the cell death-inducing DFF45-like effector-C (CIDEC) gene is involved in lipid storage and energy metabolism, suggesting that it is a potential candidate gene that affects body measurement traits (BMTs) and meat quality traits (MQTs). The aim of this study was to identify polymorphisms of the bovine CIDEC gene and analyze their possible ... more

C.G. Mei; L.S. Gui; C.Z. Fu; H.C. Wang; J.L. Wang; G. Cheng; L.S. Zan

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