Research Article

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Atherosclerosis; Bioinformatic analysis; Differentially-expressed genes; Familial hypercholesterolemia; Mechanism

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Ala16Val polymorphism; APOE gene polymorphism; Atherosclerosis; MnSOD gene polymorphism; ox-LDL; Oxidative damage; Oxidative stress

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Atherosclerosis; Mitochondrial DNA; Type 2 diabetes mellitus

Hyperglycemia-induced reactive oxygen species production can cause diabetes and its complications, including atherosclerosis. The role of mitochondrial DNA variants and mitochondrial copy number in the pathogenesis of diabetic atherogenesis is not well understood. We examined 36 diabetic patients who had undergone amputation for diabetic foot and seven non-diabetic patients who had ... more

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Atherosclerosis; Mononuclear cell; Stress; β2-AR

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Y.L. Guo; J.Q. Zhou; C.Q. Xiang; W.H. Yang; B. Zhang; W.J. Dai; J.H. Liu; S.J. Zheng
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Atherosclerosis; Global DNA methylation; Homocysteine; Lectin-like oxidized LDL receptor-1

Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change in endothelial cells. ApoE-/- mice were divided into a ... more

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Angiotensin-1; Atherosclerosis; Endothelial nitric oxide synthase; Endothelin-1; Vascular function

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Atherosclerosis; Diabetes mellitus; Diabetic foot; High mobility group box 1; Peripheral arterial occlusive disease

The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabetic patients, including 29 ... more

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Aortic valve calcification; Atherosclerosis; Soluble receptor for advanced glycation end-products

The soluble receptor for advanced glycation end-products (sRAGE) shows a close relationship with atherosclerosis. The goal of this study was to compare the levels of sRAGE in patients with and without aortic valve calcification and to investigate the relationship between them. After transthoracic echocardiographic examination, 120 male patients with aortic valve calcification and 120 age ... more

H. Zheng; Y. Li; N. Xie; J.L. Huang; H.F. Xu; M. Luo
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Atherosclerosis; Fibroblast growth factor-23; Peritoneal dialysis

Several previous studies have demonstrated that elevated levels of fibroblast growth factor-23 (FGF-23) may be involved in atherosclerosis and contribute to the high mortality rate of peritoneal dialysis (PD) patients. The aim of this study was to determine the precise role of FGF-23 in the pathogenesis of atherosclerosis in PD patients. Between April 2009 and January 2012, 62 PD patients ... more

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