Research Article

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12/09/2015
Breast cancer; MTHFR; Polymorphism; Risk

We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length ... more

X.F. Zhang; T. Liu; Y. Li; S. Li
10/27/2015
Head and neck cancer; MTHFR; Radiotherapy

The C677T and A1298C polymorphisms in methylene­tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous cell carcinoma (HNSCC) may respond ... more

Q.S. Anders; E. Stur; L.P. Agostini; F.M. Garcia; R.S. Reis; J.A. Santos; S.O. Mendes; L.L. Maia; G.T. Peterle; V. Stange; M.B. Carvalho; E.H. Tajara; M. Santos; A.M.A. Silva-Conforti; I.D. Louro
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C677T polymorphism; Colorectal cancer; Hypermethylation; Methylenetetrahydrofolate reductase; Microsatellite instability; MTHFR

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Considering that methylation abnormalities appear to be important for the ... more

A.D. Clarizia; L. Bastos-Rodrigues; H.B. Pena; C. Anacleto; B. Rossi; A. Lopes; J.Cláudio C. Rocha; O. Caballero; A. Camargo; A.J.G. Simpson; S.D.J. Pena; F.A. Soares
12/14/2011
Colorectal cancer risk; Genotype; Haplotype; MTHFR

Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C ... more

H. Li; W.L. Xu; H.L. Shen; Q.Y. Chen; L.L. Hui; L.L. Long; X.L. Zhu
06/21/2011
Colorectal cancer; Kashmir; MTHFR; Polymorphism; Restriction digestion; RFLP

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been ... more

A.S. Sameer; Z.A. Shah; S. Nissar; S. Mudassar; M.A. Siddiqi
06/22/2010
C677T polymorphism; Folate; Homocysteine; MTHFR; Vitamin B12

Association between neural tube defects (NTDs) and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was suspected, because the MTHFR gene codes for a key enzyme in folate metabolism. Its deficiency usually leads to significant reductions in plasma concentrations of folate, vitamin B12 and methionine, whereas homocysteine levels are increased. We ... more

M.O. Erdogan; S.H. Yildiz; M. Solak; O. Eser; E. Cosar; B. Eser; R. Koken; S. Buyukbas
10/29/2013
Folate; Glioma; MGMT; MTHFR; Polymorphisms

Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation. As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may ... more

N. Liu; J. Jiang; Y.J. Song; S.G. Zhao; Z.G. Tong; H.S. Song; H. Wu; J.Y. Zhu; Y.H. Gu; Y. Sun; W. Hua; J.P. Qi
10/31/2014
Breast cancer; Folate; MTHFR; Polymorphism; Vitamin

We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were ... more

J.M. He; Y.D. Pu; Y.J. Wu; R. Qin; Q.J. Zhang; Y.S. Sun; W.W. Zheng; L.P. Chen
09/29/2014
A1298C polymorphism; C677T polymorphism; Ethnic groups; Mixteca; MTHFR; Nahua

In this study, we examined the distribution of genotype and allele frequencies of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase gene (MTHFR) in two ethnic groups in the State of Guerrero, Mexico, which were compared with those of the Mestizo population of the region. A comparative study was conducted on 455 women from two ethnic groups and a group ... more

V. Antonio-Véjar; O. del Moral-Hernández; L.C. Alarcón-Romero; E. Flores-Alfaro; M.A. Leyva-Vázquez; D. Hernández-Sotelo; B. Illades-Aguiar
07/24/2014
Breast cancer; Folate; MTHFR; Polymorphism

We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population. A 1:1-matched case-control study was conducted. Two hundred and thirty patients who were newly diagnosed and histologically confirmed breast cancer and 230 controls were enrolled from Xinxiang ... more

Z.G. Wang; W. Cui; L.F. Yang; Y.Q. Zhu; W.H. Wei

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