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Related GMR Articles

Androgen receptor; Chromosome X; Exon 1; Exon 4; Male infertility

The androgen receptor is encoded by a single-copy gene located in the long arm of the X chromosome (Xq11-12); it consists of eight exons and encodes an intracellular transcription factor that belongs to the steroid/nuclear receptor superfamily. Disturbances in the function of the androgen receptor can lead to several forms of male pseudohermaphroditism, such as androgen insensitivity syndrome ... more

C.O.A. Melo; A.R. Danin; D.M. Silva; J.A. Tacon; K.K.V.O. Moura; E.O.A. Costa; A.D. da Cruz
estrogen; Estrogen receptor-α; Estrogen receptor-β; Male infertility; Spermatogenesis

Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results. The present study was conducted to examine whether polymorphisms within the ERα and ERβ genes are susceptibility factors for human male idiopathic infertility in Chinese men. We investigated the association between the ERα gene and ... more

J. Meng; X. Mu; Y.M. Wang
Hemiptera; Nucleolus; Spermatogenesis; Spermiogenesis; Testicular lobes

We studied the karyotype, spermatogenesis and nucleolar activity at spermatogenesis in five species of Heteropera: Hyalymenus sp and Neomegalotomus pallescens, Alydidae; Catorhintha guttula and Hypselonotus fulvus, Coreidae; and Niesthrea sidae, Rhopalidae. They showed a red (Alydidae) or orange (Coreidae and Rhopalidae) membrane covering the ... more

H.V. Souza; F.B. Souza; S.R.C. Maruyama; M.M.U. Castanhole; M.M. Itoyama
Assisted human reproduction; AZF; Male infertility; Y microdeletions

Microdeletions in Yq are associated with defects in spermatogenesis, while those in the AZF region are considered critical for germ cell development. We examined microdeletions in the Y chromosomes of patients attended at the Laboratory of Human Reproduction of the Clinical Hospital of the Federal University of Goiás as part of a screening of patients who plan to undergo assisted ... more

J.T. Arruda; B.M. Bordin; P.R. Santos; W.E.J.C. Mesquita; R.C.P.C. Silva; M.C.S. Maia; M.S. Approbato; R.S. Florêncio; W.N. Amaral; M.A.Rocha Filho; K.K.V.O. Moura
GSTM1; GSTT1; Male infertility; Xenobiotics

Male infertility is a heterogeneous disorder, with vari­ous genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxi­fying enzymes of phase II drug metabolism can modify their expres­sion or function, affecting the biotransformation of toxic ... more

A.C.F. Finotti; R.C.P.Costa e Silva; B.M. Bordin; C.T.X. Silva; K.K.V.O. Moura
Azoospermia; Chromosomal abnormality; Male infertility; Severe oligozoospermia; Y chromosome microdeletion

Infertility is defined as the inability to conceive a child after one year of regular unprotected intercourse; it is a major health problem affecting about 10-15% of all couples. Infertility is due to a male factor in approximately 50% of cases. The human Y chromosome contains genes necessary for gonadal differentiation into a testis and genes for complete spermatogenesis. We examined the ... more

G.G. Ceylan; C. Ceylan; H. Elyas
Male infertility; vertical transmission; Y chromosome

Male infertility is considered to be a difficult-to-treat condition because it is not a single entity, but rather reflects a variety of different pathologic conditions, thus making it difficult to use a single treatment strategy. Structural alterations in the Y chromosome have been the principal factor responsible for male infertility. We examined 26 family members of 13 patients with male ... more

R.G. Rodovalho; J.T. Arruda; K.K.V.O. Moura
AZF regions; Male infertility; STS markers; Y-chromosome microdeletion

Infertility is a major reproductive health threat; the frequency of male infertility due to Y-chromosome microdeletions is 13-18% in the human population; these microdeletions involve recurrent loss of three non-overlapping regions designated as AZFa, AZFb and AZFc, associated with spermatogenic failure. Several contradictory reports have been published regarding deletion frequency based ... more

L.K. Pandey; S. Pandey; J. Gupta; A.K. Saxena
Familial Mediterranean fever; Male infertility; Mediterranean fever gene

Male infertility is a common barrier that prevents successful conception. There have been reports of azoospermia in men with familial Mediterranean fever, some of whom had not been treated with colchicine. Variation in this disorder could be a risk factor for amyloidosis associated with azoospermia. We determined the frequency of 6 of the most common Mediterranean fever gene mutations, ... more

E.O. Etem; D. Erol; Y. Huseyin; A. Arslan
chromosome; Klinefelter’s syndrome; Male infertility; Preimplantation genetic diagnosis; Prenatal diagnosis

The purpose of this study was to detect chromosomal aberrations and azoospermia factor (AZF) microdeletions in male patients with reproductive problems and to summarize related clinical features to provide reliable information for evaluating prenatal and preimplantation diagnoses. A large cohort of 5083 men with various phenotypes of male infertility was analyzed via G-banding karyotyping ... more

Q. Quan; T.J. Li; X.P. Ding; J. Wei; L.X. Li; L. Fu