Research Article

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COL1A1; Gene polymorphism; Meta-analysis; Osteoporosis

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
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Insulin-like growth factors; Osteoporosis; Polymorphism

We conducted a case-control study to assess the relation­ship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to ... more

W. Zhang; L.C. Zhang; H. Chen; P.F. Tang; L.H. Zhang
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Catechol-O-methyl transferase; Cytochrome P450 17; Estrogen receptor 1; Osteoporosis; Polymorphism

In this study, we evaluated genetic factors related to the mineral density during post-menopause. We evaluated 110 women in the first 5 years post-menopause, without previous hormone replacement therapy. Cytochrome P450 17 (CYP17) (rs743572), catechol-O-methyl transferase (COMT) (rs4680), and estrogen receptor 1 (ESR1) (rs9322331) were examined for the ... more

C.G. Gonçalves; B.C. Almeida; C.M. Camargo-Kosugi; A.M.M. Costa; I.D.C.G. Silva; M.A. Haidar
11/13/2015
Insulin-like growth factors; Osteoporosis; Polymorphism; Postmenopausal female

The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the study between 2012 and 2014. ... more

Y.K. Wei; H.L. Ma; Y.Z. Guo; B.H. Yang; W.X. Pang
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Alendronate regulates the activity of osteoclasts and healing of osteoporosis. This study investigated the effect of alendronate on bone healing and changes in the levels of cytokines. Bilateral ovaries of 10 adult female rabbits were removed surgically in aseptic condition to establish the animal model of osteoporosis. Five rabbits in group A were treated with alendronate (1.15 mg·kg·week) ... more

C.T. Liu; X.J. Yuan; G.C. Gao
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Calcium and vitamin D; Cross- sectional; Exercise; Fosamax drug; Lifestyle; Menopause; Osteoporosis; Prevalence; T-score

Osteoporosis is a common pathology and a cause of disability and reduced quality of life invarious developing countries.  An urgent issue in this context is the study of risk factors for osteoporosis, especially those that can be modified. We conducted a cross-sectional study in Vietnam.  The study was conducted in the city of Vinh and involved 2065 respondents who ... more

S.C. Thuc; T.H.L. Thi; M.T.N. Thi; H.D. Vinh
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We assessed the effectiveness of Aclasta for osteoporosis in patients with femoral head fractures at Thong Nhat Hospital in Ho Chi Minh City. A total of 156 patients with femoral head fractures and osteoporosis in the orthopedic department at Thong Nhat in Ho Chi Minh City were assigned to a randomized controlled trial from 01 Jan 2013 to 01 Jan 2014, divided into ... more

V.T. Toan; B.V. Anh
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BMP-2; Bone morphogenetic protein 2; Decorin; Fracture nonunion; Osteogenesis transformation

Bone morphogenetic protein 2 (BMP-2) can promote fracture healing. Although the complex role BMP-2 in bone formation is increasingly understood, the role of endogenous BMP-2 in nonunion remains unclear. Decorin (DCN) can promote the formation of bone matrix and calcium deposition to control bone morphogenesis. In this study, tissue composition and expression of BMP-2 and DCN were detected ... more

X.G. Han; D.K. Wang; F. Gao; R.H. Liu; Z.G. Bi
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BMP-2; Cell signaling; Daidzein; Osteoblast; Phytoestrogen; Smad

Daidzein, the most widely studied soy phytoestrogen, is not only a potential antiosteoporosis agent owing to its possible osteogenic activity, but also shows anticancer activity. However, the mechanisms through which daidzein affects osteoblast function have not been investigated thoroughly. Here, we show that daidzein stimulated cell proliferation and differentiation of osteoblasts, ... more

B. Hu; B. Yu; D. Tang; S. Li; Y. Wu; B. Hu; B. Yu; D. Tang; S. Li; Y. Wu