Research Article

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A1298C polymorphism; C677T polymorphism; Ethnic groups; Mixteca; MTHFR; Nahua

In this study, we examined the distribution of genotype and allele frequencies of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase gene (MTHFR) in two ethnic groups in the State of Guerrero, Mexico, which were compared with those of the Mestizo population of the region. A comparative study was conducted on 455 women from two ethnic groups and a group ... more

V. Antonio-Véjar; O. del Moral-Hernández; L.C. Alarcón-Romero; E. Flores-Alfaro; M.A. Leyva-Vázquez; D. Hernández-Sotelo; B. Illades-Aguiar
A1298C polymorphism; Hepatocellular carcinoma; Methylenetetrahydrofolate reductase (MTHFR)

The A1298C polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be associated with hepatocellular carcinoma (HCC), but there are conflicting results from previous studies. The present study aimed to investigate the association between this polymorphism and the risk of HCC using a meta-analysis of the published studies. Published literature ... more

W. Chang; Q. Meng; J.H. Liu; L.X. Wu; Y. Chen; S.D. Chen
Arg188His; Gene polymorphism; Ovarian cancer; X-ray repair cross-complementing group 2 (XRCC2)

Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-analysis. Quality ... more

M. Zhai; Y. Wang; M.F. Jiang
Nuclear factor-kB; Ovarian cancer; Single nucleotide polymorphisms

Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 ... more

L.P. Chen; P.S. Cai; H.B. Liang
Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

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Cytokine array; Ovarian cancer; Survival curve; Th1-Th2 balance

The balance between type 1 and type 2 T helper cells (the Th1-Th2 balance) is closely correlated with cancer, but the correlation in ovarian cancer remains unconfirmed. We investigated the Th1-Th2 balance for the diagnosis, treatment, and prognostic evaluation of ovarian cancer. Fifty healthy subjects and 50 ovarian cancer patients were recruited. The levels of various cytokines were ... more

C.J. Hao; J. Li; P. Liu; X.L. Li; Y.Q. Hu; J.C. Sun; Y. Wei; C.J. Hao; J. Li; P. Liu; X.L. Li; Y.Q. Hu; J.C. Sun; Y. Wei
miR-146a; miR-196a2; Ovarian cancer; Polymorphism

We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by polymerase chain ... more

X.C. Sun; A.C. Zhang; L.L. Tong; K. Wang; X. Wang; Z.Q. Sun; H.Y. Zhang; X.C. Sun; A.C. Zhang; L.L. Tong; K. Wang; X. Wang; Z.Q. Sun; H.Y. Zhang
Cancer stem cells; CD44; Meta-analysis; Outcome; Ovarian cancer

This meta-analysis study aimed to investigate the correlation between CD44-positive cancer stem cells (CSCs) and clinicopathological features and its effect on the survival of ovarian cancer patients. A comprehensive literature search in the electronic databases, including PubMed, EMBASE, and Wanfang (up to December 1, 2015), was conducted. Publications assessing the clinical or ... more

Y.Y. Shi; H. Jiang; Y.Y. Shi; H. Jiang